Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients.

Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Research Abstract Details 

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Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Abstract Text:

Gyorgy Petrovics,Wei Zhang,Mazen Makarem,Jesse P Street,Roger Connelly,Leon Sun,Isabell A Sesterhenn,Vasantha Srikantan,Judd W Moul,Shiv Srivastava,

PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.

Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Publishing Authors By Initials

G Petrovics,W Zhang,M Makarem,JP Street,R Connelly,L Sun,IA Sesterhenn,V Srikantan,JW Moul,S Srivastava,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research

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Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Oncogene

VOLUME: 23

Page Numbers: 605-11

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 15

MONTH: Jan

YEAR: 2004

Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Keywords Mesh Terms:

KEYWORDS: Prostatic Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Information

Substance Name: PCGEM1 non-coding RNA, human

Registry Number: 0

Grant and Affiliation Information for Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients.

AFFILIATION: Department of Surgery, Center for Prostate Disease Research, US Military Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. gpetrovics@cpdr.org

Country: England

AGENCY: United States NCI

GRANT: 1R01CA85596-01

ACRONYM: CA

MEDLINETA: Oncogene

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