Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal.

Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Research Abstract Details 

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Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Abstract Text:

The DNA-binding activity of the transcription factors AP-1, CREB and OCT was investigated in nuclear extracts of brains from rats undergoing ethanol withdrawal. AP-1 DNA-binding activity but not that of CREB or OCT was increased in the cerebral cortex, hippocampus and cerebellum 15 and 17 hr after ethanol withdrawal. A similar increase in AP-1 binding activity was observed in subcortical structures at 17 hr of ethanol withdrawal. No change in any transcription factor DNA-binding activity was observed in the brain stem. Our results suggest that increased expression of immediate early genes is coupled with an increase in DNA-binding function, indicating that they may play a role in the long-term molecular response to ethanol withdrawal.

Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Publishing Authors By Initials

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 2

Page Numbers: 223-7

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ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1994

Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Information

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LANGUAGE: eng

NlmUniqueID: 8804836

Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Elevated AP-1 DNA-binding activity in rat brain during ethanol withdrawal.

AFFILIATION: Department of Biochemistry, University of Queensland, St Lucia, Australia.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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