Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY).

Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Research Abstract Details 

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Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Abstract Text:

Dennis R Sparta,Jon R Fee,Darin J Knapp,George R Breese,Todd E Thiele,Dennis R Sparta,Jon R Fee,Darin J Knapp,George R Breese,Todd E Thiele,

BACKGROUND: Neuropeptide Y (NPY) is a neuromodulator with anxiolytic properties. Recent evidence suggests that NPY modulates neurobiological responses to ethanol. Because withdrawal from ethanol is associated with elevated anxiety-like behavior, and because central NPY modulates anxiety, we assessed anxiety-like behavior in mutant mice lacking normal production of NPY (NPY-/-) and in normal wild-type mice (NPY+/+) 6h after removal of a liquid diet containing 4.5% ethanol. METHODS: NPY-/- and NPY+/+ mice on a pure 129/SvEv genetic background were given 6 days of access to a liquid ethanol diet (ED) or control diet (CD). Six hours before elevated plus maze (EPM) testing, ED was replaced with CD in the ethanol-withdrawn group. RESULTS: Ethanol-withdrawn NPY-/- mice showed significantly less open arm time and total proportion of time spent in the open arm of the EPM relative to ethanol-withdrawn NPY+/+ mice and when compared to NPY-/- and NPY+/+ mice that had access to the CD. On the other hand, ethanol-withdrawn NPY+/+ mice did not show altered EPM behavior relative to controls. CONCLUSIONS: Central NPY is protective against anxiety-like behavior stemming from exposure to and/or withdrawal from ethanol. Targets aimed at NPY receptors may be useful compounds for treating anxiety associated with ethanol dependence.

Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Publishing Authors By Initials

DR Sparta,JR Fee,DJ Knapp,GR Breese,TE Thiele,DR Sparta,JR Fee,DJ Knapp,GR Breese,TE Thiele,

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Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Drug and alcohol dependence

VOLUME: 90

Page Numbers: 297-300

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ISSN: 0376-8716

DAY: 4

MONTH: 05

YEAR: 2007

Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Information

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LANGUAGE: eng

NlmUniqueID: 7513587

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Grant and Affiliation Information for Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY).

AFFILIATION: Department of Psychology, University of North Carolina, Chapel Hill, NC 27599-3270, USA.

Country: Ireland

AGENCY: United States NIAAA

GRANT: R01 AA015148-02

ACRONYM: AA

MEDLINETA: Drug Alcohol Depend

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