Elegance, silence and nonsense in the mutations literature for solid tumors.

Elegance, silence and nonsense in the mutations literature for solid tumors. Research Abstract Details 

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Elegance, silence and nonsense in the mutations literature for solid tumors. Abstract Text:

Scott E Kern,Jordan M Winter,

A third of highly cited clinical studies are subsequently contradicted, and there are statistical reasons for why many published research findings may be false. The subjective impression of many experts in cancer genetics is that much of the tumor mutation literature may also be erroneous or deeply flawed. For example, there exist many reports of false somatic mutations attributable entirely to the choice of analytic method. This pattern of mis-reporting may divert the investment of limiting resources for cancer research into fundamentally flawed directions. We provide here a review of the basic theoretic principles and observed patterns within the literature of solid tumors and inherited tumor-susceptibility syndromes. These patterns provide support for a systematic approach to the critical analysis of the somatic mutation literature offered in the accompanying paper.

Elegance, silence and nonsense in the mutations literature for solid tumors. Publishing Authors By Initials

SE Kern,JM Winter,

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Elegance, silence and nonsense in the mutations literature for solid tumors. Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer biology & therapy

VOLUME: 5

Page Numbers: 349-59

Journal Abbreviation: Cancer Biol. Ther.

ISSN: 1538-4047

DAY: 1

MONTH: 04

YEAR: 2006

Elegance, silence and nonsense in the mutations literature for solid tumors. Information

Number of References: 140

LANGUAGE: eng

NlmUniqueID: 101137842

Elegance, silence and nonsense in the mutations literature for solid tumors. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: genetics

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Grant and Affiliation Information for Elegance, silence and nonsense in the mutations literature for solid tumors.

AFFILIATION: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. sk@jhmi.edu

Country: United States

AGENCY: United States NIDDK

GRANT: T32-DK007713

ACRONYM: DK

MEDLINETA: Cancer Biol Ther

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