Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids.

Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Research Abstract Details 

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Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Abstract Text:

Robert Konecny,Joanna Trylska,Florence Tama,Deqiang Zhang,Nathan A Baker,Charles L Brooks,J A McCammon,

Electrostatic properties of cowpea chlorotic mottle virus (CCMV) and cucumber mosaic virus (CMV) were investigated using numerical solutions to the Poisson-Boltzmann equation. Experimentally, it has been shown that CCMV particles swell in the absence of divalent cations when the pH is raised from 5 to 7. CMV, although structurally homologous, does not undergo this transition. An analysis of the calculated electrostatic potential confirms that a strong electrostatic repulsion at the calcium-binding sites in the CCMV capsid is most likely the driving force for the capsid swelling process during the release of calcium. The binding interaction between the encapsulated genome material (RNA) inside of the capsid and the inner capsid shell is weakened during the swelling transition. This probably aids in the RNA release process, but it is unlikely that the RNA is released through capsid openings due to unfavorable electrostatic interaction between the RNA and capsid inner shell residues at these openings. Calculations of the calcium binding energies show that Ca(2+) can bind both to the native and swollen forms of the CCMV virion. Favorable binding to the swollen form suggests that Ca(2+) ions can induce the capsid contraction and stabilize the native form.

Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Publishing Authors By Initials

R Konecny,J Trylska,F Tama,D Zhang,NA Baker,CL Brooks,JA McCammon,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biopolymers

VOLUME: 82

Page Numbers: 106-20

Journal Abbreviation: Biopolymers

ISSN: 0006-3525

DAY: 5

MONTH: Jun

YEAR: 2006

Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Information

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LANGUAGE: eng

NlmUniqueID: 372525

Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: secretion

Chemical & Substance for Abstract: Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids.

AFFILIATION: Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, 92093-0365, USA. rok@ucsd.edu

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM069702-04

ACRONYM: GM

MEDLINETA: Biopolymers

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