Electrostatic origin of the genome packing in viruses.

Electrostatic origin of the genome packing in viruses. Research Abstract Details 

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Electrostatic origin of the genome packing in viruses. Abstract Text:

Vladimir A Belyi,M Muthukumar,

Many ssRNA/ssDNA viruses bind their genome by highly basic semiflexible peptide arms of capsid proteins. Here, we show that nonspecific electrostatic interactions control both the length of the genome and genome conformations. Analysis of available experimental data shows that the genome length is linear in the net charge on the capsid peptide arms, irrespective of the actual amino acid sequence, with a proportionality coefficient of 1.61 +/- 0.03. This ratio is conserved across all ssRNA/ssDNA viruses with highly basic peptide arms, and is different from the one-to-one charge balance expected of specific binding. Genomic nucleotides are predicted to occupy a radially symmetric spherical shell detached from the viral capsid, in agreement with experimental data.

Electrostatic origin of the genome packing in viruses. Publishing Authors By Initials

VA Belyi,M Muthukumar,

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Electrostatic origin of the genome packing in viruses. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 17174-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 7

MONTH: 11

YEAR: 2006

Electrostatic origin of the genome packing in viruses. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Electrostatic origin of the genome packing in viruses. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: chemistry

Chemical & Substance for Abstract: Electrostatic origin of the genome packing in viruses. Information

Substance Name: Peptides

Registry Number: 0

Grant and Affiliation Information for Electrostatic origin of the genome packing in viruses.

AFFILIATION: Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA.

Country: United States

AGENCY: United States NHGRI

GRANT: 1R01HG002776-01

ACRONYM: HG

MEDLINETA: Proc Natl Acad Sci U S A

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