Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration.

Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Research Abstract Details 

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Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Abstract Text:

Yingshan Zhou,Dongzhi Yang,Xiangmei Chen,Qiang Xu,Fengmin Lu,Jun Nie,Yingshan Zhou,Dongzhi Yang,Xiangmei Chen,Qiang Xu,Fengmin Lu,Jun Nie,Yingshan Zhou,Dongzhi Yang,Xiangmei Chen,Qiang Xu,Fengmin Lu,Jun Nie,

Biocompatible carboxyethyl chitosan/poly(vinyl alcohol) (CECS/PVA) nanofibers were successfully prepared by electrospinning of aqueous CECS/PVA solution. The composite nanofibrous membranes were subjected to detailed analysis by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). SEM images showed that the morphology and diameter of the nanofibers were mainly affected by the weight ratio of CECS/PVA. XRD and DSC demonstrated that there was strong intermolecular hydrogen bonding between the molecules of CECS and PVA. The crystalline microstructure of the electrospun fibers was not well developed. The potential use of the CECS/PVA electrospun fiber mats as scaffolding materials for skin regeneration was evaluated in vitro using mouse fibroblasts (L929) as reference cell lines. Indirect cytotoxicity assessment of the fiber mats indicated that the CECS/PVA electrospun mat was nontoxic to the L929 cell. Cell culture results showed that fibrous mats were good in promoting the cell attachment and proliferation. This novel electrospun matrix would be used as potential wound dressing for skin regeneration.

Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Publishing Authors By Initials

Y Zhou,D Yang,X Chen,Q Xu,F Lu,J Nie,Y Zhou,D Yang,X Chen,Q Xu,F Lu,J Nie,Y Zhou,D Yang,X Chen,Q Xu,F Lu,J Nie,

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Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomacromolecules

VOLUME: 9

Page Numbers: 349-54

Journal Abbreviation: Biomacromolecules

ISSN: 1526-4602

DAY: 8

MONTH: 12

YEAR: 2007

Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Information

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LANGUAGE: eng

NlmUniqueID: 100892849

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Grant and Affiliation Information for Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration.

AFFILIATION: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.

Country: United States

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MEDLINETA: Biomacromolecules

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