Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds.

Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Research Abstract Details 

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Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Abstract Text:

Yuan Ji,Kaustabh Ghosh,Xiao Zheng Shu,Bingquan Li,Jonathan C Sokolov,Glenn D Prestwich,Richard A F Clark,Miriam H Rafailovich,

A three-dimensional (3D) hyaluronic acid (HA) nanofibrous scaffold was successfully fabricated to mimic the architecture of natural extracellular matrix (ECM) based on electrospinning. Thiolated HA derivative, 3,3'-dithiobis(propanoic dihydrazide)-modified HA (HA-DTPH), was synthesized and electrospun to form 3D nanofibrous scaffolds. In order to facilitate the fiber formation during electrospinning, Poly (ethylene oxide) (PEO) was added into the aqueous solution of HA-DTPH at an optimal weight ratio of 1:1. The electrospun HA-DTPH/PEO blend scaffold was subsequently cross-linked through poly (ethylene glycol)-diacrylate (PEGDA) mediated conjugate addition. PEO was then extracted in DI water to obtain an electrospun HA-DTPH nanofibrous scaffold. NIH 3T3 fibroblasts were seeded on fibronectin-adsorbed HA-DTPH nanofibrous scaffolds for 24h in vitro. Fluorescence microscopy and laser scanning confocal microscopy revealed that the 3T3 fibroblasts attached to the scaffold and spread, demonstrating an extended dendritic morphology within the scaffold, which suggests potential applications of HA-DTPH nanofibrous scaffolds in cell encapsulation and tissue regeneration.

Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Publishing Authors By Initials

Y Ji,K Ghosh,XZ Shu,B Li,JC Sokolov,GD Prestwich,RA Clark,MH Rafailovich,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biomaterials

VOLUME: 27

Page Numbers: 3782-92

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 23

MONTH: 03

YEAR: 2006

Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Information

Substance Name: Hyaluronic Acid

Registry Number: 9004-61-9

Grant and Affiliation Information for Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds.

AFFILIATION: Department of Materials Science and Engineering, SUNY at Stony Brook, Stony Brook, NY 11794-2275, USA.

Country: England

AGENCY: United States NIDCD

GRANT: DC004336

ACRONYM: DC

MEDLINETA: Biomaterials

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