Electron tunneling chains of mitochondria.

Electron tunneling chains of mitochondria. Research Abstract Details 

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Electron tunneling chains of mitochondria. Abstract Text:

Christopher C Moser,Tammer A Farid,Sarah E Chobot,P Leslie Dutton,

The single, simple concept that natural selection adjusts distances between redox cofactors goes a long way towards encompassing natural electron transfer protein design. Distances are short or long as required to direct or insulate promiscuously tunneling single electrons. Along a chain, distances are usually 14 A or less. Shorter distances are needed to allow climbing of added energetic barriers at paired-electron catalytic centers in which substrate and the required number of cofactors form a compact cluster. When there is a short-circuit danger, distances between shorting centers are relatively long. Distances much longer than 14 A will support only very slow electron tunneling, but could act as high impedance signals useful in regulation. Tunneling simulations of the respiratory complexes provide clear illustrations of this simple engineering.

Electron tunneling chains of mitochondria. Publishing Authors By Initials

CC Moser,TA Farid,SE Chobot,PL Dutton,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

PUBMED ID PMID:

MEDLINE DATE:

Electron tunneling chains of mitochondria. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochimica et biophysica acta

VOLUME: 1757

Page Numbers: 1096-109

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 5

MONTH: 05

YEAR: 2006

Electron tunneling chains of mitochondria. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217513

Electron tunneling chains of mitochondria. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: metabolism

Chemical & Substance for Abstract: Electron tunneling chains of mitochondria. Information

Substance Name: Electron Transport Complex IV

Registry Number: EC 1.9.3.1

Grant and Affiliation Information for Electron tunneling chains of mitochondria.

AFFILIATION: The Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, 1005, Stellar-Chance Laboratories, 422, Curie Boulevard, Philadelphia, PA 19104-6059, USA. moserc@mail.med.upenn.edu

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM27309

ACRONYM: GM

MEDLINETA: Biochim Biophys Acta

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