Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide.

Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide. Research Abstract Details 

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Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide. Abstract Text:

Sangchul Rho,Deokjin Jahng,Jae Hoon Lim,Jinsub Choi,Jeong Ho Chang,Sang Cheon Lee,Kyung Ja Kim,Sangchul Rho,Deokjin Jahng,Jae Hoon Lim,Jinsub Choi,Jeong Ho Chang,Sang Cheon Lee,Kyung Ja Kim,

Electrochemical DNA biosensors based on a thin gold film sputtered on anodic porous niobium oxide (Au@Nb(2)O(5)) are studied in detail here. We found that the novel DNA biosensor based on Au@Nb(2)O(5) is superior to those based on the bulk gold electrode or niobium oxide electrode. For example, the novel method does not require any time-consuming cleaning step in order to obtain reproducible results. The adhesion of gold films on the substrate is very stable during electrochemical biosensing, when the thin gold films are deposited on anodically prepared nanoporous niobium oxide. In particular, the novel biosensor shows enhanced biosensing performance with a 2.4 times higher resolution and a three times higher sensitivity. The signal enhancement is in part attributed to capacitive interface between gold films and nanoporous niobium oxide, where charges are accumulated during the anodic and cathodic scanning, and is in part ascribed to the structural stability of DNA immobilized at the sputtered gold films. The method allows for the detection of single-base mismatch DNA as well as for the discrimination of mismatch positions.

Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide. Publishing Authors By Initials

S Rho,D Jahng,JH Lim,J Choi,JH Chang,SC Lee,KJ Kim,S Rho,D Jahng,JH Lim,J Choi,JH Chang,SC Lee,KJ Kim,

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Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biosensors & bioelectronics

VOLUME: 23

Page Numbers: 852-6

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ISSN: 0956-5663

DAY: 11

MONTH: 09

YEAR: 2007

Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Electrochemical DNA biosensors based on thin gold films sputtered on capacitive nanoporous niobium oxide.

AFFILIATION: Department of Environmental Engineering and Biotechnology, Myongji University, Yongin, Gyunggi-do 449-728, South Korea.

Country: England

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MEDLINETA: Biosens Bioelectron

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