Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes.

Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Research Abstract Details 

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Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Abstract Text:

Joseph Wang,Tanin Tangkuaram,Suchera Loyprasert,Terannie Vazquez-Alvarez,Waret Veerasai,Proespichaya Kanatharana,Panote Thavarungkul,

A bilayer surface coating, prepared by electrodepositing ruthenium oxide (RuOx) onto a carbon nanotube (CNT) layer, offers dramatic improvements in the stability and sensitivity of voltammetric and amperometric measurements of insulin compared to the individual (CNT or RuOx) coated electrodes. The enhanced electrocatalytic activity towards insulin is indicated from lowering the potential of the oxidation process (starting around 0.35 versus Ag/AgCl) and the substantially higher sensitivity over the entire potential range. A wide linear dynamic range (10-800 nM) was achieved with a detection limit of 1 nM. The marked electrocatalytic activity of the RuOx/CNT coating towards insulin is coupled with a greatly enhanced stability. For example, the insulin amperometric response of the RuOx/CNT-coated electrodes is highly stable, with 97% of the initial activity remaining after 60 min stirring of 2 x 10(-6) M solution (compared to significantly faster current diminutions at the RuOx- or CNT-coated surfaces). The results suggest great promise for miniaturized sensors and detectors for monitoring insulin.

Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Publishing Authors By Initials

J Wang,T Tangkuaram,S Loyprasert,T Vazquez-Alvarez,W Veerasai,P Kanatharana,P Thavarungkul,

For similar inorganic chemicals: ruthenium compounds research abstracts see: inorganic chemicals: ruthenium compounds research

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Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Analytica chimica acta

VOLUME: 581

Page Numbers: 1-6

Journal Abbreviation: Anal. Chim. Acta

ISSN: 1873-4324

DAY: 7

MONTH: 08

YEAR: 2006

Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Information

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LANGUAGE: eng

NlmUniqueID: 370534

Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Keywords Mesh Terms:

KEYWORDS: Ruthenium Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Electrocatalytic detection of insulin at RuOx/carbon nanotube-modified carbon electrodes.

AFFILIATION: Departments of Chemical and Material Engineering, Chemistry and Biochemistry, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5801, USA. joseph.wang@asu.edu <joseph.wang@asu.edu>

Country: Netherlands

AGENCY: United States EPO

GRANT: R01 EP 0002189

ACRONYM: EP

MEDLINETA: Anal Chim Acta

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