Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current.

Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current. Research Abstract Details 

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Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current. Abstract Text:

J P Couderc,M Vaglio,X Xia,S McNitt,O Hyrien,J P Couderc,M Vaglio,X Xia,S McNitt,O Hyrien,

Several important non-cardiac drugs have been removed from the market after revealing harmful effect that was not identified during prior safety-assessment studies. We developed a new technique for the measurements of repolarization abnormalities from surface ECGs; this method improves sensitivity and specificity of the current technique used to identify the presence of abnormal ion current kinetics in the myocardial cells namely a prolongation of the QT interval on the surface ECG signal. We described in this paper the method and preliminary results, revealing the superiority of our technique that may play a role in the future of drug-safety assessment.

Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current. Publishing Authors By Initials

JP Couderc,M Vaglio,X Xia,S McNitt,O Hyrien,JP Couderc,M Vaglio,X Xia,S McNitt,O Hyrien,

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Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 4010-5

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ISSN: 1557-170X

DAY: 23

MONTH: 10

YEAR: 2006

Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current. Information

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LANGUAGE: eng

NlmUniqueID: 101243413

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AFFILIATION: Rochester Univ., NY.

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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