Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications.

Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Research Abstract Details 

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Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Abstract Text:

Yi Guo,Mengyan Li,Andreas Mylonakis,Jingjia Han,Alan G MacDiarmid,Xuesi Chen,Peter I Lelkes,Yen Wei,Yi Guo,Mengyan Li,Andreas Mylonakis,Jingjia Han,Alan G MacDiarmid,Xuesi Chen,Peter I Lelkes,Yen Wei,Yi Guo,Mengyan Li,Andreas Mylonakis,Jingjia Han,Alan G MacDiarmid,Xuesi Chen,Peter I Lelkes,Yen Wei,

A novel electroactive silsesquioxane precursor, N-(4-aminophenyl)-N'-(4'-(3-triethoxysilyl-propyl-ureido) phenyl-1,4-quinonenediimine) (ATQD), was successfully synthesized from the emeraldine form of amino-capped aniline trimers via a one-step coupling reaction and subsequent purification by column chromatography. The physicochemical properties of ATQD were characterized using mass spectrometry as well as by nuclear magnetic resonance and UV-vis spectroscopy. Analysis by cyclic voltammetry confirmed that the intrinsic electroactivity of ATQD was maintained upon protonic acid doping, exhibiting two distinct reversible oxidative states, similar to polyaniline. The aromatic amine terminals of self-assembled monolayers (SAMs) of ATQD on glass substrates were covalently modified with an adhesive oligopeptide, cyclic Arg-Gly-Asp (RGD) (ATQD-RGD). The mean height of the monolayer coating on the surfaces was approximately 3 nm, as measured by atomic force microscopy. The biocompatibility of the novel electroactive substrates was evaluated using PC12 pheochromocytoma cells, an established cell line of neural origin. The bioactive, derivatized electroactive scaffold material, ATQD-RGD, supported PC12 cell adhesion and proliferation, similar to control tissue-culture-treated polystyrene surfaces. Importantly, electroactive surfaces stimulated spontaneous neuritogenesis in PC12 cells, in the absence of neurotrophic growth factors, such as nerve growth factor (NGF). As expected, NGF significantly enhanced neurite extension on both control and electroactive surfaces. Taken together, our results suggest that the newly electroactive SAMs grafted with bioactive peptides, such as RGD, could be promising biomaterials for tissue engineering.

Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Publishing Authors By Initials

Y Guo,M Li,A Mylonakis,J Han,AG MacDiarmid,X Chen,PI Lelkes,Y Wei,Y Guo,M Li,A Mylonakis,J Han,AG MacDiarmid,X Chen,PI Lelkes,Y Wei,Y Guo,M Li,A Mylonakis,J Han,AG MacDiarmid,X Chen,PI Lelkes,Y Wei,

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Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomacromolecules

VOLUME: 8

Page Numbers: 3025-34

Journal Abbreviation: Biomacromolecules

ISSN: 1525-7797

DAY: 11

MONTH: 09

YEAR: 2007

Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications. Information

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LANGUAGE: eng

NlmUniqueID: 100892849

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Grant and Affiliation Information for Electroactive oligoaniline-containing self-assembled monolayers for tissue engineering applications.

AFFILIATION: Department of Chemistry and School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: DE09848

ACRONYM: DE

MEDLINETA: Biomacromolecules

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