Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials.

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Abstract Text:

Michael E Knash,Aiko Kido,Monica Gorassini,K Ming Chan,Richard B Stein,

Motor-evoked potentials (MEP) in the tibialis anterior (TA) muscle were shown to be facilitated by repetitive electrical stimulation of the common peroneal (CP) nerve at intensities above motor threshold. The TA electromyogram (EMG) and ankle flexion force were recorded in response to transcranial magnetic stimulation (TMS) of the leg area of the motor cortex to evaluate the excitability of cortico-spinal-muscular pathways. Repetitive stimulation of the CP nerve at 25 Hz for 30 min increased the MEP by 50.3 +/- 13.6% (mean +/- S.E.) at a TMS intensity that initially gave a half-maximum MEP (MEPh). In contrast the maximum MEP (MEPmax) did not change. Ankle flexion force (103 +/- 21.9%) and silent period duration (75.3 +/- 12.9%) also increased. These results suggest an increase in corticospinal excitability, rather than total connectivity due to repetitive CP stimulation. Facilitation was evident after as little as 10 min of stimulation and persisted without significant decrement for at least 30 min after stimulation. The long duration of silent period following CP stimulation (99.2 +/- 14.8 ms) suggests that this form of stimulation may have effects on the motor cortex. To exclude the possibility that MEPh facilitation was primarily due to sensory fibre activation, we performed several control experiments. Preferentially activating Ia muscle afferents by vibration in the absence of motor activity had no significant effect. Cutaneous afferent activation via stimulation of the superficial peroneal nerve increased the amplitude of responses at MEPmax rather than MEPh. Concurrent tendon vibration and superficial peroneal nerve stimulation failed to facilitate TA MEP responses. In summary, repetitive electrical stimulation of the CP nerve elicits lasting changes in corticospinal excitability, possibly as a result of co-activating motor and sensory fibres.

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Publishing Authors By Initials

ME Knash,A Kido,M Gorassini,KM Chan,RB Stein,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

PUBMED ID PMID:

MEDLINE DATE:

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 153

Page Numbers: 366-77

Journal Abbreviation:

ISSN: 0014-4819

DAY: 12

MONTH: 09

YEAR: 2003

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: innervation

Chemical & Substance for Abstract: Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials.

AFFILIATION: Centre for Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials Related Publications

• Alterations in intranuclear localization of Runx2 affect biological activity.
• Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.
• Can differences in breast cancer utilities explain disparities in breast cancer care?
• Characterization of small amounts of peptides and proteins.
• Choosing earlier therapy for muscle-invasive bladder cancer.
• Comparability of functional MRI response in young and old during inhibition.
• Coping and burden among informal HIV caregivers.
• Correlates of condom use and reasons for condom non-use among drug users.
• Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype.
• Disability and poor quality of life associated with comorbid anxiety disorders and physical conditions.
• Eating disorders and substance use; An examination of behavioral associations.
• Endothelial dysfunction, erectile dysfunction, and coronary heart disease: the pathophysiologic and clinical linkage.
• Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells.
• In search of mixed anxiety-depressive disorder: a primary care study.
• Is the ankle-brachial index a useful screening test for subclinical atherosclerosis in asymptomatic, middle-aged adults?
• Managing concomitant cardiac disease and erectile dysfunction.
• Natural History: Wheeze from childhood to adulthood.
• Pathologic guidelines for orthotopic urinary diversion in women with bladder cancer: a review of the literature.
• Plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects.
• Post-traumatic stress disorder in children.
• Pregnancy attitudes and contraceptive plans among women entering jail.
• Rate controlling steps in fatty acid oxidation by unloaded rodent soleus muscle.
• Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.
• Relocation of older australians.
• Self-cognitions in antisocial alcohol dependence and recovery.
• Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase.
• Slow-release and injected progesterone treatments enhance acute recovery after traumatic brain injury.
• The development of cortical multisensory integration.
• The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury.
• The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT.