Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery.

Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Research Abstract Details 

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Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Abstract Text:

Brian J Mossop,Roger C Barr,Joshua W Henshaw,David A Zaharoff,Fan Yuan,

The intratumoral field, which determines the efficiency of electric field-mediated drug and gene delivery, can differ significantly from the applied field. Therefore, we investigated the distribution of the electric field in mouse tumors and tissue phantoms exposed to a large range of electric stimuli, and quantified the resistances of tumor, skin, and electrode-tissue interface. The samples used in the study included 4T1 and B16.F10 tumors, mouse skin, and tissue phantoms constructed with 1% agarose gel with or without 4T1 cells. When pulsed electric fields were applied to samples using a pair of parallel-plate electrodes, we determined the electric field and resistances in each sample as well as the resistance at the electrode-tissue interface. The electric fields in the center region of tissue phantoms and tumor slices ex vivo were macroscopically uniform and unidirectional between two parallel-plate electrodes. The field strengths in tumor tissues were significantly lower than the applied field under both ex vivo and in vivo conditions. During in vivo stimulation, the ratio of intratumoral versus applied fields was approximately either 20% or 55%, depending on the applied field. Meanwhile, the total resistance of skin and electrode-tissue interface was decreased by approximately 70% and the electric resistance at the center of both tumor models was minimally changed when the applied field was increased from 50 to 400 V/cm. These results may be useful for improving electric field-mediated drug and gene delivery in solid tumors.

Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Publishing Authors By Initials

BJ Mossop,RC Barr,JW Henshaw,DA Zaharoff,F Yuan,

For similar equipment and supplies: phantoms, imaging research abstracts see: equipment and supplies: phantoms, imaging research

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Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Annals of biomedical engineering

VOLUME: 34

Page Numbers: 1564-72

Journal Abbreviation:

ISSN: 0090-6964

DAY: 19

MONTH: 08

YEAR: 2006

Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Information

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LANGUAGE: eng

NlmUniqueID: 361512

Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Keywords Mesh Terms:

KEYWORDS: Phantoms, Imaging

MESH TERMS: therapy

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Grant and Affiliation Information for Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery.

AFFILIATION: Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC 27708, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA94019

ACRONYM: CA

MEDLINETA: Ann Biomed Eng

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