Electric field-induced changes in membrane proteins charge movement currents.

Electric field-induced changes in membrane proteins charge movement currents. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Electric field-induced changes in membrane proteins charge movement currents. Abstract Text:

Wei Chen,Wen-hui Wu,

Our previous study showed that thermal effects induced by Joule heating did not play the pivotal role in damage of membrane proteins when cell membranes were shocked by a pulsed membrane potential up to 500 mV. Our analytical study of ion channel currents further indicated that a brief electric shock may cause protein conformational damage in the channel gating system, resulting in a reduction in the number of limiting gating charge particles. In this paper, we present the results of our study into electric shock-induced changes in the intramembrane charge movement currents. We found that a brief electric shock may significantly alter the characteristics of the charge movement currents of the membrane proteins, including reducing the magnitudes of two components Q(beta) and Q(gamma), broadening the hump shape of Q(gamma), and increasing its time delay. This study suggests that a brief intensive electric shock may cause proteins to structurally alter, reducing the amount of movable charge particles and therefore decreasing the protein functions. These results indicate that electro-coupled structural damage in membrane proteins is an important mechanism involved in electrical injury, especially in a field range not sufficient to cause thermal damage.

Electric field-induced changes in membrane proteins charge movement currents. Publishing Authors By Initials

W Chen,WH Wu,

For similar animals: chordata: vertebrates: amphibia: anura: ranidae: rana pipiens research abstracts see: animals: chordata: vertebrates: amphibia: anura: ranidae: rana pipiens research

PUBMED ID PMID:

MEDLINE DATE:

Electric field-induced changes in membrane proteins charge movement currents. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Burns : journal of the International Society for B

VOLUME: 32

Page Numbers: 833-41

Journal Abbreviation:

ISSN: 0305-4179

DAY: 26

MONTH: 09

YEAR: 2006

Electric field-induced changes in membrane proteins charge movement currents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8913178

Electric field-induced changes in membrane proteins charge movement currents. Keywords Mesh Terms:

KEYWORDS: Rana pipiens

MESH TERMS: physiology

Chemical & Substance for Abstract: Electric field-induced changes in membrane proteins charge movement currents. Information

Substance Name: Membrane Proteins

Registry Number: 0

Grant and Affiliation Information for Electric field-induced changes in membrane proteins charge movement currents.

AFFILIATION: Laboratory for Cellular and Molecular Biophysics, Department of Physics, The University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA. Wchen@cas.usf.edu

Country: England

AGENCY: United States NIGMS

GRANT: 2R01 GM 50785

ACRONYM: GM

MEDLINETA: Burns

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Electric field-induced changes in membrane proteins charge movement currents Related Publications

• Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.
• Clinical analysis of 4 cases of juvenile granulosa cell tumor of the ovary.
• Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.
• Effects of As(2)O(3) on BCR-ABL protein level and signal transduction in CML cells.
• Etiological analysis on the ocular fungal infection.
• Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow.
• Monocyte chemoattractant protein-1 mRNA in human intracranial aneurysm walls.
• Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms.
• Significance of HER-2/neu expression in ovarian epithelial tumours.
• Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop.
• Study on some mechanism of leucite microcrystallization to reinforce dental glass ceramics.
• The clinical study of lateral orbitotomy.
• The expression, characterization and roles of macrophage colony-stimulating factor receptor in human leukemia cell lines.
• Thermal hyperalgesic effects induced by intracerebroventricular injection of interleukin-1beta in rats.
• [Arsenic exposure of residents in areas near Shimen arsenic mine]
• [Clinical study of treatment with continuous renal replacement therapy on severe hepatitis with hepatic encephalopathy]
• [Content of metals in different diameter airborne particles and effect on micronuclei formation in human lymphocytes]
• [Detection of monosomy 7 or 7q- in cases of myelodysplastic syndrome]
• [Determination of triptolide in tripterygium preparations by gradient high performance liquid chromatography]
• [Discussion on the concept problem of the specific retention volume in gas chromatography]
• [Effect of recombinant human bone morphogenetic protein-2 on the expression of osteopontin in human periodontal ligament cells]
• [Liver sinusoidal endothelial cell damage during normothermic ischemia and reperfusion of rat]
• [Oral combination chemotherapy of 5'-deoxy-5-fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer]
• [Pathological features of atrial isomerism and its diagnosis by computed tomography]
• [Preliminary study on the molecular mechanism of K562 cell apoptosis induced by As2S2]
• [Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease]
• [Screening and identification of egg mimotope of Schistosoma japonicum]
• [Studies on immunoprotection in mice after immunization with Schistosoma japonicum 22.6 kDa recombinant protein]
• [Study of acute physiology and chronic health evaluation III and multiple organ dysfunction syndrome score in evaluating severity of intensive care units patient]
• [Study on hepatic-protective effect of "yinzhihuang" granula]