Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus.

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Abstract Text:

OBJECTIVE: The goal of this project was to develop a quantitative understanding of the volume of axonal tissue directly activated by deep brain stimulation (DBS) of the subthalamic nucleus (STN). METHODS: The 3-dimensionally inhomogeneous and anisotropic tissue medium surrounding DBS electrodes complicates our understanding of the electric field and tissue response generated by the stimulation. We developed finite element computer models to address the effects of DBS in a homogeneous isotropic medium, and a medium with tissue conductivity properties derived from human diffusion tensor magnetic resonance data. The second difference of the potential distribution generated in the tissue medium was used as a predictor of the volume of tissue supra-threshold for axonal activation. RESULTS: The model predicts that clinically effective stimulation parameters (-3 V; 0.1 ms; 150 Hz) result in activation of large diameter (5.7 microm) myelinated axons over a volume that spreads outside the borders of the STN. The shape of the activation volume was dependent on the strong dorsal-ventral anisotropy of the internal capsule, and the moderate anterior-posterior anisotropy of the region around zona incerta. CONCLUSIONS: Small deviations ( approximately 1 mm) in the electrode position within STN can substantially alter the shape of the activation volume as well as its spread to neighboring structures. SIGNIFICANCE: STN DBS represents an effective treatment for medically refractory movement disorders such as Parkinson's disease. However, stimulation induced side effects such as tetanic muscle contraction, speech disturbance and ocular deviation are not uncommon. Quantitative characterization of the spread of stimulation will aid in the development of techniques to maximize the efficacy of DBS.

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical neurophysiology : official journal of the

VOLUME: 115

Page Numbers: 589-95

Journal Abbreviation: Clin Neurophysiol

ISSN: 1388-2457

DAY: 10

MONTH: Mar

YEAR: 2004

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883319

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Keywords Mesh Terms:

KEYWORDS: Principal Component Analysis

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus.

AFFILIATION: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. mcintyre@bme.ri.ccf.org

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Neurophysiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus Related Publications

• Accessory meningeal artery: an anatomic misnomer.
• Analytic environment-dependent tight-binding bond integrals: application to MoSi2.
• Angioplasty of arteries in the carotid territory.
• Automatic preparation of computer models.
• COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.
• Carotid artery stenting in elderly patients: Importance of case selection.
• Department of Ophthalmology, University of Alabama, School of Medicine, Birmingham.
• Differences in antitumor effects of various statins on human pancreatic cancer.
• Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus.
• Facial reflexes.
• Fatal cerebral hemorrhage early after subclavian artery endovascular therapy.
• Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: Possible protective effects and therapeutic applications of bilirubin.
• Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues.
• Improved HPLC Analysis of Serum 7{alpha}-Hydroxycholest-4-en-3-one, a Marker of Bile Acid Malabsorption.
• In re: arterial dissection complicating cerebral angiography and cerebrovascular interventions.
• Mechanisms and targets of deep brain stimulation in movement disorders.
• Not Available
• Pallidal burst activity during therapeutic deep brain stimulation.
• Percutaneous transluminal angioplasty of the carotid artery.
• Percutaneous transluminal angioplasty of the external carotid artery.
• Results of percutaneous transluminal angioplasty.
• The persistent effects of unilateral pallidal and subthalamic deep brain stimulation on force control in advanced Parkinson's patients.
• Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both.
• [Craniocerebral and medullary cervicogenic syndrome.]
• [EFFECT OF LYSENYL, DESERIL AND OTHER SEROTONIN ANTAGONISTS ON BIOCHEMICAL SYSTEMS.]
• [Expression of presenilin 1 on the cell surface in motile polarized cells]
• [Thrombocytopathia and pseudohaemophilia.]