Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation.

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Abstract Text:

Megan N Ballinger,Tracy R McMillan,Bethany B Moore,

Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for a number of malignant and inherited disorders. However, the efficacy of this therapy is limited by a number of serious infectious and noninfectious complications. Pulmonary infections represent a significant cause of morbidity and mortality post-HSCT and can occur both pre- and post-hematopoietic reconstitution. Susceptibility to Gram-negative bacterial infections despite full hematopoietic engraftment suggests that innate immunity remains impaired months to years post-HSCT. This review will describe the process and complications of HSCT and will summarize what is known about innate immune reconstitution post-HSCT. Data from the literature as well as our own laboratory will be presented to suggest that an eicosanoid imbalance characterized by over-production of prostaglandins and under-production of leukotrienes leads to impaired lung phagocyte function post-HSCT. Of therapeutic interest, strategies which limit production of prostaglandins can improve pulmonary host defense in animal HSCT models, which suggests that this may also be beneficial for human HSCT recipients.

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Publishing Authors By Initials

MN Ballinger,TR McMillan,BB Moore,

For similar respiratory system: lung research abstracts see: respiratory system: lung research

PUBMED ID PMID:

MEDLINE DATE:

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Journal Published:

PUBLICATION TYPE: Review

Journal: Archivum immunologiae et therapiae experimentalis

VOLUME: 55

Page Numbers: 1-12

Journal Abbreviation: Arch. Immunol. Ther. Exp. (War

ISSN: 0004-069X

DAY: 3

MONTH: 12

YEAR: 2007

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Information

Number of References: 106

LANGUAGE: eng

NlmUniqueID: 114365

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Keywords Mesh Terms:

KEYWORDS: Lung

MESH TERMS: metabolism

Chemical & Substance for Abstract: Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Information

Substance Name: Eicosanoids

Registry Number: 0

Grant and Affiliation Information for Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation.

AFFILIATION: University of Michigan, Ann Arbor, MI, USA.

Country: Switzerland

AGENCY: United States NHLBI

GRANT: P50HL56402

ACRONYM: HL

MEDLINETA: Arch Immunol Ther Exp (Warsz)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation Related Publications

• After HRT: What now?
• Analysis of milk urea nitrogen and lactose and their effect on longevity in Canadian dairy cattle.
• Anthropological reflections on youth drug use research in Australia: what we don't know and how we should find out.
• Beyond Zinberg's 'social setting': a processural view of illicit drug use.
• CNS entrepreneurs: innovators in patient care.
• Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro.
• Consultant appraisals. Turned to good account.
• Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation.
• Ectopic glial tissue in the occipital scalp.
• Effects of stent design parameters on normal artery wall mechanics.
• Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes.
• Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping.
• Hazardous alcohol use: a risk factor for non-adherence and lack of suppression in HIV infection.
• Health-related quality of life and support group attendance for patients with systemic lupus erythematosus.
• Introducing world journal of emergency surgery.
• Legal aspects of conserving native oysters in Scotland.
• Medically unnecessary emergency medical services (EMS) transports among children ages 0 to 17 years.
• Migration, law, and the public's health.
• Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis.
• Parkin: a multifaceted ubiquitin ligase.
• Penetrating social worlds: conducting ethnographic research into alcohol and other drug use within Australia.
• Prediction of absolute thresholds and equal-loudness contours using a modified loudness model.
• Primary care groups. Back to basics.
• Principles and practice of drug photodegradation studies.
• Quick-splitting of bovine embryos.
• Southern analysis using methyl-sensitive restriction enzymes.
• Stromal cell lines from the aorta-gonado-mesonephros region are potent supporters of murine and human hematopoiesis.
• The role of chemical signals in the social behavior of crayfish.
• Untangling the role of amyloid in atherosclerosis.
• Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection.