EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells.

EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Research Abstract Details 

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EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Abstract Text:

Jin Pu,Colin D McCaig,Lin Cao,Zhiqiang Zhao,Jeffrey E Segall,Min Zhao,

The mechanisms by which cancer cells migrate to metastasise are not fully understood. Breast cancers are accompanied by electrical depolarisation of tumour epithelial cells. The electrical changes can be detected on the skin and are used to differentiate malignant from benign breast tumours. Could the electrical signals play a role in metastasis by promoting tumour cell migration? We report that electric fields stimulate and direct migration of human breast cancer cells. Importantly, these effects were more significant in highly metastatic tumour cells than in low metastatic tumour cells. Electric-field-enhanced directional migration correlates well with the expression level of EGF receptor (EGFR/ErbB1). To confirm this, we transfected low metastatic clone MTC cells with human ErbB1, which significantly increased the electrotactic response. Inhibition of ErbB1 completely abolished the directional response of MTLn3 cells to an electric field. Transfection of MTLn3 cells and MDA-MB-435 cells with expression vectors for ErbB family members ErbB1, ErbB2 and ErbB3 also significantly enhanced EF-induced migration. These results suggest that electric signals might play a role in metastasis of breast cancers by enhancing cell migration through the ErbB-signalling pathway.

EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Publishing Authors By Initials

J Pu,CD McCaig,L Cao,Z Zhao,JE Segall,M Zhao,

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EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 3395-403

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 1

MONTH: Oct

YEAR: 2007

EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 52457

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Grant and Affiliation Information for EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells.

AFFILIATION: School of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Country: England

AGENCY: United Kingdom Wellcome T

GRANT: 068012

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MEDLINETA: J Cell Sci

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