Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards.

Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards. Research Abstract Details 

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Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards. Abstract Text:

Christian Wolf,Hanhui Xu,Christian Wolf,Hanhui Xu,

A series of sterically hindered biaryls have been obtained by palladium- and nickel-phosphinous acid-catalyzed Kumada-Corriu cross-coupling of ortho-substituted aryl halides and Grignard reagents. This method allows formation of di- and tri-ortho-substituted biaryls in 87-98% yield under mild reaction conditions even when electron-rich aryl chlorides are used. The reaction also proceeds with aryl iodides at -20 degrees C, and under these conditions, functional groups that are generally not compatible with Grignard reagents are tolerated.

Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards. Publishing Authors By Initials

C Wolf,H Xu,C Wolf,H Xu,

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Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of organic chemistry

VOLUME: 73

Page Numbers: 162-7

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ISSN: 0022-3263

DAY: 6

MONTH: 12

YEAR: 2007

Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards. Information

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LANGUAGE: eng

NlmUniqueID: 2985193

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Grant and Affiliation Information for Efficient synthesis of sterically crowded biaryls by palladium-phosphinous Acid-catalyzed cross-coupling of aryl halides and aryl grignards.

AFFILIATION: Department of Chemistry, Georgetown University, Washington, D.C. 20057.

Country: United States

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MEDLINETA: J Org Chem

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