Efficient multipoint mapping: making use of dominant repulsion-phase markers.

Efficient multipoint mapping: making use of dominant repulsion-phase markers. Research Abstract Details 

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Efficient multipoint mapping: making use of dominant repulsion-phase markers. Abstract Text:

D I Mester,Y I Ronin,Y Hu,J Peng,E Nevo,A B Korol,

The paper is devoted to the problem of multipoint gene ordering with a particular focus on "dominance" complication that acts differently in conditions of coupling-phase and repulsion-phase markers. To solve the problem we split the dataset into two complementary subsets each containing shared codominant markers and dominant markers in the coupling-phase only. Multilocus ordering in the proposed algorithm is based on pairwise recombination frequencies and using the well-known travelling salesman problem (TSP) formalization. To obtain accurate results, we developed a multiphase algorithm that includes synchronized-marker ordering of two subsets assisted by re-sampling-based map verification, combining the resulting maps into an integrated map followed by verification of the integrated map. A new synchronized Evolution-Strategy discrete optimization algorithm was developed here for the proposed multilocus ordering approach in which common codominant markers facilitate stabilization of the marker order of the two complementary maps. High performance of the employed algorithm allows systematic treatment for the problem of verification of the obtained multilocus orders, based on computing-intensive bootstrap and jackknife technologies for detection and removing unreliable marker scores. The efficiency of the proposed algorithm was demonstrated on simulated and real data.

Efficient multipoint mapping: making use of dominant repulsion-phase markers. Publishing Authors By Initials

DI Mester,YI Ronin,Y Hu,J Peng,E Nevo,AB Korol,

For similar natural sciences: mathematics research abstracts see: natural sciences: mathematics research

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Efficient multipoint mapping: making use of dominant repulsion-phase markers. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: TAG. Theoretical and applied genetics. Theoretisch

VOLUME: 107

Page Numbers: 1102-12

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ISSN: 0040-5752

DAY: 20

MONTH: 08

YEAR: 2003

Efficient multipoint mapping: making use of dominant repulsion-phase markers. Information

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LANGUAGE: eng

NlmUniqueID: 145600

Efficient multipoint mapping: making use of dominant repulsion-phase markers. Keywords Mesh Terms:

KEYWORDS: Mathematics

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Chemical & Substance for Abstract: Efficient multipoint mapping: making use of dominant repulsion-phase markers. Information

Substance Name: Genetic Markers

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Grant and Affiliation Information for Efficient multipoint mapping: making use of dominant repulsion-phase markers.

AFFILIATION: Institute of Evolution, University of Haifa, Mt. Carmel, Haifa 31905, Israel.

Country: Germany

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MEDLINETA: Theor Appl Genet

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