Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex.

Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex. Research Abstract Details 

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Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex. Abstract Text:

Xiaoqiang Chen,Jingyun Wang,Shiguo Sun,Jiangli Fan,Song Wu,Jianfeng Liu,Saijian Ma,Lizhu Zhang,Xiaojun Peng,Xiaoqiang Chen,Jingyun Wang,Shiguo Sun,Jiangli Fan,Song Wu,Jianfeng Liu,Saijian Ma,Lizhu Zhang,Xiaojun Peng,

Inspired by the structures of natural nucleases, guanidinium groups were introduced into binuclear iron(III) systems. Compared with the corresponding analogue without guanidinium groups, the new diiron(III) system led to considerable rate enhancement on DNA cleavage. The cooperativity between metal ions and guanidine groups was evidenced by the fact that no significant cleavage was observed after incubating pBR322 plasmid DNA with non-metalated ligands or free Fe3+ ion. DNA binding experiments indicated that introduction of positively charged guanidinium groups can obtain more than one order of magnitude enhancement in the affinity of complex with DNA.

Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex. Publishing Authors By Initials

X Chen,J Wang,S Sun,J Fan,S Wu,J Liu,S Ma,L Zhang,X Peng,X Chen,J Wang,S Sun,J Fan,S Wu,J Liu,S Ma,L Zhang,X Peng,

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Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 109-13

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 5

MONTH: 11

YEAR: 2007

Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex.

AFFILIATION: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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