Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma.

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Research Abstract Details 

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Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Abstract Text:

Guru Sonpavde,Norihiko Okuno,Heidi Weiss,Jiang Yu,Steven S Shen,Mamoun Younes,Weiguo Jian,Seth P Lerner,Carolyn L Smith,

OBJECTIVES: To evaluate estrogen receptors as a therapeutic target for human bladder cancer. METHODS: The ability of the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene to inhibit 5637 human transitional cell carcinoma cell proliferation was determined in vitro and in xenograft studies using 5637 cells in female athymic BALB/c nu/nu mice. RESULTS: Treatment with tamoxifen, raloxifene, or the pure antiestrogen ICI 182,780 inhibited proliferation of 5637 cells in vitro. In the first xenograft study, raloxifene (10, 100, or 1000 microg/day) administered by oral gavage inhibited the growth of tumors compared with placebo or untreated controls (P <0.05). In a second experiment, tamoxifen (8.3, 125, or 1250 microg/day) delivered by time-release pellet inhibited tumor growth compared with placebo-treated controls (P <0.01). A comparison study in which tamoxifen (8.3 or 125 microg/day) or raloxifene (100 microg/day) was administered by slow-release pellet demonstrated that both SERMs reduced growth compared to placebo-treated controls (P <0.05), with comparable effectiveness. There was no detectable tumor in 17 of 30 treated mice. In all studies, average tumor volumes in SERM-treated animals declined over the course of treatment. CONCLUSIONS: Selective estrogen receptor modulators inhibit the growth of 5637 transitional cell carcinoma cell xenografts, supporting the rationale to evaluate these agents as targeted therapeutics for patients with urothelial carcinoma.

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Publishing Authors By Initials

G Sonpavde,N Okuno,H Weiss,J Yu,SS Shen,M Younes,W Jian,SP Lerner,CL Smith,

For similar neoplasms: neoplasms by site: urogenital neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms research

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MEDLINE DATE:

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Urology

VOLUME: 69

Page Numbers: 1221-6

Journal Abbreviation: Urology

ISSN: 1527-9995

DAY: 3

MONTH: Jun

YEAR: 2007

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 366151

Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Keywords Mesh Terms:

KEYWORDS: Urogenital Neoplasms

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Information

Substance Name: Raloxifene

Registry Number: 84449-90-1

Grant and Affiliation Information for Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma.

AFFILIATION: U.S. Oncology Research, Webster, Texas, USA.

Country: United States

AGENCY: United States NCI

GRANT: P20 CA103698

ACRONYM: CA

MEDLINETA: Urology

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