Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma.

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Abstract Text:

Toshiya Kamiyama,Kazuaki Nakanishi,Hideki Yokoo,Munenori Tahara,Takahito Nakagawa,Hirofumi Kamachi,Hiroshi Taguchi,Hiroki Shirato,Michiaki Matsushita,Satoru Todo,Toshiya Kamiyama,Kazuaki Nakanishi,Hideki Yokoo,Munenori Tahara,Takahito Nakagawa,Hirofumi Kamachi,Hiroshi Taguchi,Hiroki Shirato,Michiaki Matsushita,Satoru Todo,Toshiya Kamiyama,Kazuaki Nakanishi,Hideki Yokoo,Munenori Tahara,Takahito Nakagawa,Hirofumi Kamachi,Hiroshi Taguchi,Hiroki Shirato,Michiaki Matsushita,Satoru Todo,Toshiya Kamiyama,Kazuaki Nakanishi,Hideki Yokoo,Munenori Tahara,Takahito Nakagawa,Hirofumi Kamachi,Hiroshi Taguchi,Hiroki Shirato,Michiaki Matsushita,Satoru Todo,

BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) in the main trunk or the first branch is very poor. METHODS: Radiotherapy (RT) to PVTT was followed by hepatectomy within 2 weeks. The dose used was 30-36 Gy, in 10-12 fractions, for 15-20 days. The efficacy of preoperative RT to PVTT in the main trunk or first branch was evaluated by comparing results in patients who underwent hepatectomy (group R; n = 15) with preoperative RT and those without preoperative RT (group N; n = 28). RESULTS: The 1-, 3-, and 5-year survival rates in group R were 86.2%, 43.5%, and 34.8%, respectively, while these values in group N were 39.0%, 13.1%, and 13.1%, respectively. The survival curve of group R was significantly better than that of group N (P = 0.0359). In group R, five (83.3%) of six patients whose tumor thrombus was completely necrosed (based on pathological examination) and whose follow-up period was over 2 years survived for more than 2 years. Female sex (P = 0.0066), multiple tumors (P = 0.0369), and absence of preoperative RT (P = 0.0359) were ranked as significant factors for a poor prognosis by univariate analysis. Multivariate analysis revealed absence of preoperative RT and female sex to be significant factors for a poor prognosis. CONCLUSION: Preoperative RT to PVTT in the main trunk or first branch improved the prognosis of patients with HCC with PVTT, and could be a promising new modality in the treatment of these patients.

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Publishing Authors By Initials

T Kamiyama,K Nakanishi,H Yokoo,M Tahara,T Nakagawa,H Kamachi,H Taguchi,H Shirato,M Matsushita,S Todo,T Kamiyama,K Nakanishi,H Yokoo,M Tahara,T Nakagawa,H Kamachi,H Taguchi,H Shirato,M Matsushita,S Todo,T Kamiyama,K Nakanishi,H Yokoo,M Tahara,T Nakagawa,H Kamachi,H Taguchi,H Shirato,M Matsushita,S Todo,T Kamiyama,K Nakanishi,H Yokoo,M Tahara,T Nakagawa,H Kamachi,H Taguchi,H Shirato,M Matsushita,S Todo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of clinical oncology / Japan

VOLUME: 12

Page Numbers: 363-8

Journal Abbreviation: Int. J. Clin. Oncol.

ISSN: 1341-9625

DAY: 22

MONTH: 10

YEAR: 2007

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9616295

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma.

AFFILIATION: The Department of General Surgery, Graduate School of Medicine, Hokkaido University, North 5, West 7, Kita-ku, Sapporo 060-8638, Japan. t-kamiya@med.hokudai.ac.jp

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Clin Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma Related Publications

• A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys.
• A novel tumor necrosis factor-alpha suppressant, ONO-SM362, prevents liver failure and promotes liver regeneration after extensive hepatectomy.
• A randomized controlled study of immunochemotherapy with OK-432 after curative surgery for gastric cancer.
• Contrast examination of the small bowel in patients with small-bowel transplants: findings in 16 patients.
• Cystic thymoma in a child: a rare case and review of the literature.
• Development of a convenient in vitro fertilization method using interspecific hybrids between Oryzias latipes and Oryzias curvinotus.
• Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
• Distinction between hemangioma of the liver and hepatocellular carcinoma: value of labeled RBC-SPECT scanning.
• Does the permanent portacaval shunt for a small-for-size graft in a living donor liver transplantation do more harm than good?
• Effect of Intrasplenic Transplantation of Immortalized Human Hepatocytes in the Treatment of Acetaminophen-Induced Acute Liver Failure SCID Mice.
• Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma.
• Hirschsprung's disease, acrocallosal syndrome, and congenital hydrocephalus: report of 2 patients and literature review.
• Laparoscopic liver biopsy using cup-shaped punch biopsy forceps and argon beam coagulator in children.
• Microbial flora alterations in jejunum and colon after chemical bowel preparation before Kasai hepatoportojejunostomy.
• Noble Gene Transduction Into Pancreatic beta-Cells by Singularizing Islet Cells With Low Doses of Recombinant Adenoviral Vector.
• On comparison of the accommodation in myopes wearing ordinary glasses and contact lenses.
• Oncolytic virus therapy using genetically engineered herpes simplex viruses.
• Rapidly enlarging solitary nonparasitic cyst of the liver in a child presenting as acute abdomen.
• Reply: Transient portocaval shunt for a small-for-size graft in living donor liver transplantation.
• Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
• Sudden death of a 21-year-old female with Williams syndrome showing rare complications.
• Surgical stress and tumor behavior: impact of ischemia-reperfusion and hepatic resection on tumor progression.
• The novel antioxidant edaravone: from bench to bedside.
• Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells.
• Usefulness of axial planes of helical computed tomography for diagnosis of pancreaticobiliary maljunction in early infants with negative findings on magnetic resonance cholangiopancreatography.
• [Clinical study of the effect to myocardial protection with crystalloid cardioplegic solution during open heart surgery in infants under age 3 months]
• [Comparison of accommodation of myopees wearing spectacle lenses and contact lenses]
• [Experiences of systolic arrest caused by cardioplegic solution and its possible mechanisms (author's transl)]
• [Indication, management and problems of alcoholic liver diseases for liver transplantation: current status in Japan, US and Europe]
• [Intra-graft balloon pumping--a clinical case report]