Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy.

Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Research Abstract Details 

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Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Abstract Text:

Miguel Otero,Sandra A Calarota,Anlan Dai,Anne S De Groot,Jean D Boyer,David B Weiner,

We tested a DNA vaccine strategy in order to improve the efficacy and safety of the current live smallpox vaccine involving priming with DNA vaccines and boosting with live vaccinia virus (VacV). We generated DNA plasmids encoding the A4L, A27L and H5R VacV genes. A considerable increase in antigen-specific IFN-gamma responses, high proliferative and humoral antigen-specific responses were detected in experimental primed Balb/C mice compared to controls after VacV boost. The VacV-DNA plasmids elicited IFN-gamma production in HLA-A2.1 transgenic mice in response to predicted HLA-A2.1 restricted peptide epitopes, providing valuable data for further vaccine development.

Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Publishing Authors By Initials

M Otero,SA Calarota,A Dai,AS De Groot,JD Boyer,DB Weiner,

For similar viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research abstracts see: viruses: dna viruses: poxviridae: chordopoxvirinae: orthopoxvirus: vaccinia virus research

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Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Vaccine

VOLUME: 24

Page Numbers: 4461-70

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 18

MONTH: 08

YEAR: 2005

Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8406899

Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Keywords Mesh Terms:

KEYWORDS: Vaccinia virus

MESH TERMS: immunology

Chemical & Substance for Abstract: Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd., 505 Stellar-Chance Bldg. Philadelphia, PA 19104-6100, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: U01-AI-54988

ACRONYM: AI

MEDLINETA: Vaccine

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