Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis.

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Abstract Text:

Eizo Saito,Takao Koike,Hiroshi Hashimoto,Nobuyuki Miyasaka,Yasuo Ikeda,Masako Hara,Hidehiro Yamada,Tadashi Yoshida,Masayoshi Harigai,Yoichi Ichikawa, ,Eizo Saito,Takao Koike,Hiroshi Hashimoto,Nobuyuki Miyasaka,Yasuo Ikeda,Masako Hara,Hidehiro Yamada,Tadashi Yoshida,Masayoshi Harigai,Yoichi Ichikawa,

Intravenous immunoglobulin (IVIG) therapy was administered to 15 patients who were refractory to traditional steroid therapy [eight with polymyosis (PM), seven with dermamyosis (DM)] to evaluate its efficacy. Serum creatine kinase (CK) significantly decreased from week 1, and manual muscle test scores (MMT) and activities of daily living (ADL) significantly increased from week 2. Efficacy rates were 93.3% (14/15 patients) as assessed using the MMT score, 80.0% (12/15 patients) using the ADL score, and 100% (15/15 patients) using the serum CK level. When changes in the serum CK level over two four-week periods, one before IVIG therapy (from week -4 to week 0) and one after IVIG therapy (from week 0 to week 4), were transformed to natural logarithms, the four-week change after IVIG therapy was significantly greater than that before IVIG therapy. The estimated duration of the serum CK level remaining normal in 50% of the patients after IVIG therapy was 334.5 days. Adverse reactions were observed in seven of 16 patients (43.8%) during the study period, but none of the adverse reactions were considered to be serious or required emergency treatment. In conclusion, the present study indicates that IVIG therapy is effective for steroid-resistant PM/DM.

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Publishing Authors By Initials

E Saito,T Koike,H Hashimoto,N Miyasaka,Y Ikeda,M Hara,H Yamada,T Yoshida,M Harigai,Y Ichikawa, ,E Saito,T Koike,H Hashimoto,N Miyasaka,Y Ikeda,M Hara,H Yamada,T Yoshida,M Harigai,Y Ichikawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern rheumatology / the Japan Rheumatism Associa

VOLUME: 18

Page Numbers: 34-44

Journal Abbreviation: Mod Rheumatol

ISSN: 1439-7595

DAY: 25

MONTH: 01

YEAR: 2008

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100959226

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis.

AFFILIATION: Department of Rheumatology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan, saito@oha.toho-u.ac.jp.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mod Rheumatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis Related Publications

• A cofactor protein required for actin activation of myosin Mg2+ATPase activity in leukemic myeloblasts.
• A genome-wide gain-of function analysis of rice genes using the FOX-hunting system.
• A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease.
• Activation of 1,1-difluoro-1-alkenes with a transition-metal complex: palladium(II)-catalyzed Friedel-Crafts-type cyclization of 4,4-(difluorohomoallyl)arenes.
• Analysis of Prosody in Finger Braille using Electromyography.
• Bis(triarylmethylium)-mediated diaryl ether synthesis: oxidative arylation of phenols with N,N-dialkyl-4-phenylthioanilines.
• Changes in myosin during differentiation of myeloid leukemia cells.
• Characterization of "abp38" in cytoskeleton of mouse myeloid leukemia cells and distribution of abp38 in various tissues.
• Crystalline reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase from pig adrenocortical mitochondria. Essential histidyl and cysteinyl residues of the NADPH-binding site and environment of the adrenodoxin-binding site.
• Dephosphorylation of "abp38" protein during the differentiation of mouse myeloid leukemia cells.
• Design of and metrological results from a bent parabolic mirror.
• Does Clinical Depression Affect the Accuracy of Self-reported Height and Weight in Obese Women?
• Editorial comment.
• Effects of podocyte injury on glomerular development.
• Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis.
• GPR35 is a functional receptor in rat dorsal root ganglion neurons.
• Identification of multiple regulatory elements of human L-histidine decarboxylase gene.
• Molecular identification and characterization of the dog motilin receptor.
• Prostaglandin receptors: advances in the study of EP3 receptor signaling.
• Purification and characterization of l-histidine decarboxylase from mouse mastocytoma P-815 cells.
• Purification and kinetic properties of 3 beta-hydroxysteroid dehydrogenase from bovine adrenocortical microsomes.
• Purification and properties of the tightly bound reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase of bovine adrenocortical mitochondria.
• Spontaneous rupture of common iliac artery associated with fibromuscular dysplasia presenting with colic pain suggestive of ureteral stone.
• Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
• Thermal and deformation analyses of side-cooled monochromator mirrors for the SPring-8/Figure-8 soft X-ray undulator.
• Two alternatively spliced transcripts generated from OsMUS81, a rice homolog of yeast MUS81, are up-regulated by DNA-damaging treatments.
• Zonal distribution of cytochromes P-450 and related enzymes of bovine adrenal cortex--quantitative assay of concentrations and total contents.
• [Estimation of personal dose based on the dependent calibration of personal dosimeters in interventional radiology]
• [Synthesized androgens]
• [Varicella-zoster virus meningoencephalitis without skin manifestation in an allogeneic bone marrow transplantation patient successfully treated with aciclovir]