Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.

Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China. Research Abstract Details 

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Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China. Abstract Text:

Guoshu Liu,Mingfeng Li,Xiangyun Shi, Et Al,

OBJECTIVE: To compare the efficacy and tolerability of bisoprolol, enalapril and nifedipine retard in the treatment of mild to moderate essential hypertension. METHODS: This is a randomized, double-blind, multicenter clinical trial. 331 patients with mild to moderate hypertension in the army troop were randomly allocated to receive domestic bisoprolol ( n =110,5 mg/d),enalapril ( n =111,10 mg/d) and nifedipine retard ( n =110,20 mg/day). Total duration of active drug treatment was 4 weeks. RESULTS: The total efficacy rates of domestic bisoprolol, enalapril and nifedipine retard were 80.0%, 82.0% and 81.8% respectively P > 0.05 . The incidences of adverse events were 4.5%, 8.1% and 19.1% (P < 0.01 ) in patients of bisoloprol, enalapril and nifedipine retard groups respectively. The adverse effects were mild in all the three groups. CONCLUSIONS: Domestic bisoprolol, enalapril and nifedipine retard are effective and well-tolerated in patients with mild to moderate essential hypertension. The occurrence of adverse effects were least in the bisoprolol group and most in the nifedipine retard group.

Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China. Publishing Authors By Initials

G Liu,M Li,X Shi, Et Al,

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Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Zhonghua nei ke za zhi [Chinese journal of interna

VOLUME: 41

Page Numbers: 450-2

Journal Abbreviation: Zhonghua Nei Ke Za Zhi

ISSN: 0578-1426

DAY: 21

MONTH: Jul

YEAR: 2002

Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China. Information

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LANGUAGE: eng

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AFFILIATION: Department of Cardiology, The General Hospital of PLA, Beijing 100853, China.

Country: China

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MEDLINETA: Zhonghua Nei Ke Za Zhi

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