Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome.

Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Research Abstract Details 

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Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Abstract Text:

Akira Sezai,Mitsumasa Hata,Shinji Wakui,Tetsuya Niino,Tadateru Takayama,Atsushi Hirayama,Satoshi Saito,Kazutomo Minami,Akira Sezai,Mitsumasa Hata,Shinji Wakui,Tetsuya Niino,Tadateru Takayama,Atsushi Hirayama,Satoshi Saito,Kazutomo Minami,

BACKGROUND: Low-dose continuous human atrial natriuretic peptide (hANP) administration during cardiac surgery has been reported on previously. In the present study, the efficacy of the therapy during emergent coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS) is investigated. METHODS AND RESULTS: One hundred and twenty-four patients patients undergoing emergent CABG for ACS were divided into 2 groups; a group receiving administration of hANP (hANP group) and a group not receiving hANP infusion (non-hANP group). The postoperative peak levels of creatine kinase-MB were significantly lower in the hANP group as compared with those in the non-hANP group. The incidence of postoperative arrhythmias was also significantly lower in the hANP group as compared with that in the non-hANP group. The postoperative brain natriuretic peptide was significantly lower in the hANP group as compared with that in the non-hANP group until 1 year after the operation. The free-rate of cardiac events after the operation was also significantly higher in the hANP group as compared with that in the non-hANP group. CONCLUSIONS: It is therefore considered that hANP might not only be effective for overcoming some major shortcomings of cardiopulmonary bypass, but also might be effective to attenuate ischemia-reperfusion injury, protect the myocardium, have an anti-arrhythmic effect, and suppress left ventricular remodeling.

Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Publishing Authors By Initials

A Sezai,M Hata,S Wakui,T Niino,T Takayama,A Hirayama,S Saito,K Minami,A Sezai,M Hata,S Wakui,T Niino,T Takayama,A Hirayama,S Saito,K Minami,

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Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1401-7

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 27

MONTH: Sep

YEAR: 2007

Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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AFFILIATION: Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan. asezai@med.nihon-u.ac.jp

Country: Japan

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MEDLINETA: Circ J

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