Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma.

Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Research Abstract Details 

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Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Abstract Text:

Teiji Kuzuya,Yoshiaki Katano,Takashi Kumada,Hidenori Toyoda,Isao Nakano,Yoshiki Hirooka,Akihiro Itoh,Masatoshi Ishigami,Kazuhiko Hayashi,Takashi Honda,Hidemi Goto,Teiji Kuzuya,Yoshiaki Katano,Takashi Kumada,Hidenori Toyoda,Isao Nakano,Yoshiki Hirooka,Akihiro Itoh,Masatoshi Ishigami,Kazuhiko Hayashi,Takashi Honda,Hidemi Goto,

AIM: The aim of this study was to determine whether antiviral therapy with lamivudine is beneficial in patients after initial treatment for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: Forty-nine consecutive patients with HBV-related HCC completely treated by hepatic resection or radiofrequency ablation were retrospectively enrolled in this study. Comparison was made between 16 patients who received lamivudine therapy at a dose of 100 mg/day after treatment for HCC (lamivudine group) and 33 patients who did not (control group) in terms of changes in remnant liver function, HCC recurrence and survival. RESULTS: Cumulative recurrence rates of HCC did not significantly differ between the two groups (P = 0.622). However, median Child-Pugh score at the time of HCC recurrence was significantly different; 5 (range 5-6) in the lamivudine group versus 7 (range 5-12) in the control group (P = 0.005). All patients in the lamivudine group were able to receive curative treatment for recurrent HCC. In contrast, 10 of 15 patients in the control group were unable to receive curative optimal therapy for recurrent HCC due to deterioration of remnant liver function. The cumulative survival rates of patients in the lamivudine group tended to be higher than those of patients in the control group (P = 0.063). CONCLUSION: It is suggested that lamivudine therapy is beneficial for patients after initial treatment for HBV-related HCC because it contributes to improving remnant liver function, thus decreasing the risk of liver failure and increasing the chances of receiving available treatment modalities for recurrent HCC.

Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Publishing Authors By Initials

T Kuzuya,Y Katano,T Kumada,H Toyoda,I Nakano,Y Hirooka,A Itoh,M Ishigami,K Hayashi,T Honda,H Goto,T Kuzuya,Y Katano,T Kumada,H Toyoda,I Nakano,Y Hirooka,A Itoh,M Ishigami,K Hayashi,T Honda,H Goto,

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Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of gastroenterology and hepatology

VOLUME: 22

Page Numbers: 1929-35

Journal Abbreviation: J. Gastroenterol. Hepatol.

ISSN: 0815-9319

DAY: 4

MONTH: Nov

YEAR: 2007

Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Information

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LANGUAGE: eng

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AFFILIATION: Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Country: Australia

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MEDLINETA: J Gastroenterol Hepatol

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