[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats]

[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats] Research Abstract Details 

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[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats] Abstract Text:

Jin-yu Xie,Jing-cheng Dong,Zhao-hua Gong,Jin-yu Xie,Jing-cheng Dong,Zhao-hua Gong,

OBJECTIVE: To observe the effects of Herba Epimedii and Radix Astragali, the two Chinese herbs for replenishing Shen and strengthening qi, on tumor necrosis factor-alpha (TNF-alpha, one of the pro-inflammatory factors) and nuclear factor-kappa B (NF-kappa B) in asthmatic rats. METHODS: Rats were randomly divided into five groups: the normal saline control group, the asthma model group and the three treated groups treated with high, medium and low dose of the Chinese herbs. Serum TNF-alpha and NF-kappa B activity in pulmonary tissue were detected with enzyme-linked immunosorbent assay and immunohistochemistry respectively. RESULTS: Herba Epimedii and Radix Astragali could effectively reduce the production of TNF-alpha and inhibit NF-kappa B activity, and the efficacies in the three treated group were similar, showing insignificant difference among them. CONCLUSION: Application of Herba Epimedii and Radix Astragali in the attack or remission stage of asthma could restrain the development of inflammation by reducing the production of TNF-alpha and inhibiting NF-kappa B activity.

[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats] Publishing Authors By Initials

JY Xie,JC Dong,ZH Gong,JY Xie,JC Dong,ZH Gong,

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[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongx

VOLUME: 26

Page Numbers: 723-7

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ISSN: 1003-5370

DAY: 14

MONTH: Aug

YEAR: 2006

[Effects on herba epimedii and radix astragali on tumor necrosis factor-alpha and nuclear factor-kappa B in asthmatic rats] Information

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LANGUAGE: chi

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AFFILIATION: Institute of Integrative Medicine, Huashan Hospital of Fudan University, Shanghai 200040.

Country: China

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MEDLINETA: Zhongguo Zhong Xi Yi Jie He Za

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