Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin.

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Abstract Text:

Jennifer B Keogh,Grant D Brinkworth,Peter M Clifton,Jennifer B Keogh,Grant D Brinkworth,Peter M Clifton,

Our aim was to determine whether short-term weight loss on a low-carbohydrate/low-saturated fat diet improved endothelial function compared with a conventional high-carbohydrate diet, as this diet is expected to lower both blood glucose and LDL-cholesterol. In a randomised parallel design of two energy-restricted diets in an outpatient setting, thirty-six subjects (BMI 33 (sem 4) kg/m2) were randomised to a low- or high-carbohydrate diet both low in saturated fat. Flow-mediated dilatation (FMD), fasting glucose, insulin, lipids, adiponectin and adhesion molecules were measured at baseline, during weight loss and at 52 weeks. FMD did not change with either diet (5.2 (sem 0.6) to 5.5 (sem 0.6) %) despite weight loss of 5 % and significant reductions in glucose and insulin and LDL-cholesterol and was not different after sustained weight loss of 5 % at 52 weeks. Adiponectin fell by 6 % at 12 weeks (P = 0.1) with weight loss but rose by 17 % at 12 months (P < 0.05) with 5 % weight loss. There were no effects of diet. In contradistinction, adhesion molecules fell at 12 weeks, vascular cell adhesion molecule-1 by 14 % and intracellular adhesion molecule-1 by 13 % (both P < 0.05). There were correlations between change in adiponectin at 12 months and change in HDL (r 0.778, P < 0.01) and glucose (r - 0.563, P = 0.057). In summary, weight loss does not improve FMD. Novel cardiovascular risk factors improved at 12 weeks but the improvement in adiponectin was delayed.

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Publishing Authors By Initials

JB Keogh,GD Brinkworth,PM Clifton,JB Keogh,GD Brinkworth,PM Clifton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of nutrition

VOLUME: 98

Page Numbers: 852-9

Journal Abbreviation: Br. J. Nutr.

ISSN: 0007-1145

DAY: 10

MONTH: 05

YEAR: 2007

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372547

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin.

AFFILIATION: CSIRO Human Nutrition, PO Box 10041 BC, Adelaide SA 5000, Australia. jennifer.keogh@csiro.au

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin Related Publications

• Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages.
• Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis.
• Effect of carbohydrate distribution on postprandial glucose peaks with the use of continuous glucose monitoring in type 2 diabetes.
• Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine.
• Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity.
• Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin.
• Follow-up of a case of tuberculosis of the medical malleolus of the right tibia.
• Good agreement between bioelectrical impedance and dual-energy X-ray absorptiometry for estimating changes in body composition during weight loss in overweight young women.
• Growth and assimilation in cultures of Saccharomyces cerevisiae.
• HYPOTENSION ASSOCIATED WITH TETANUS.
• High dairy-protein versus high mixed-protein energy restricted diets - the effect on bone turnover and calcium excretion in overweight adults.
• Hormones and experimental oncogenesis: mammary and mammotropic tumors.
• How tough is bone? Application of elastic-plastic fracture mechanics to bone.
• Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance.
• Male sex and pre-existing diabetes are independent risk factors for stillbirth.
• Mammalian plasma membrane proteomics.
• Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.
• Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex.
• Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects.
• Reductions in blood pressure following energy restriction for weight loss do not rebound after re-establishment of energy balance in overweight and obese subjects.
• The effect of high- and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control.
• The effect of meal replacements high in glycomacropeptide on weight loss and markers of cardiovascular disease risk.
• The effect of milk protein on the bioavailability of cocoa polyphenols.
• The effect of protein source (dairy vs mixed) in high protein, energy restricted diets on body composition, vascular health and metabolic markers in overweight adults.
• Use of monolithic supports in proteomics technology.
• WO03/062224 is an in vivo selective agonist at nicotinic beta4 receptors.
• Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats.