Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.

Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Research Abstract Details 

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Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Abstract Text:

X Chen,S S Mikhail,Y W Ding,G y Yang,F Bondoc,C S Yang,

Two well-known antioxidative nutrients, vitamin E and selenium, were used in this study to investigate possible inhibitory action against the formation of esophageal adenocarcinoma (EAC) in rats. In this model, carcinogenesis is believed to be driven by oxidative stress. Male Sprague-Dawley rats (8 weeks old) were divided into four groups and received esophagoduodenal anastomosis (EDA) surgery plus iron supplementation (12 mg/kg/week). Vitamin E and selenium were supplemented in the diet in the forms of alpha-tocopheryl acetate (750 IU/kg) and sodium selenate (1.7 mg Se/kg), which were 10 times the regular amounts in the basic AIN93M diet. At 40 weeks after surgery, all the EDA groups had lower body weights than the non-operated control group. Iron nutrition (hemoglobin, total serum iron and transferrin saturation) was normal as a result of iron supplementation after EDA. Vitamin E supplementation maintained the normal plasma level of alpha-tocopherol in EDA rats, but not those of gamma-tocopherol and retinol. Selenium supplementation increased the serum and liver selenium contents of the EDA rats. Histopathological analysis showed that selenium supplementation increased the incidence of EAC and the tumor volume. The selenium level in the tumor is higher than that in the duodenum of the same animal.Vitamin E supplementation, however, inhibited carcinogenesis, especially in the selenium-supplemented group. We believe that vitamin E exerts its effect through its antioxidative properties, and a high dose of inorganic selenium may promote carcinogenesis by enhancing oxidative stress.

Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Publishing Authors By Initials

X Chen,SS Mikhail,YW Ding,G Yang,F Bondoc,CS Yang,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Carcinogenesis

VOLUME: 21

Page Numbers: 1531-6

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 19

MONTH: Aug

YEAR: 2000

Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Information

Substance Name: Iron-Dextran Complex

Registry Number: 9004-66-4

Grant and Affiliation Information for Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats.

AFFILIATION: Laboratory for Cancer Research, College of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Country: ENGLAND

AGENCY: United States NIEHS

GRANT: ES05022

ACRONYM: ES

MEDLINETA: Carcinogenesis

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