[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Abstract Text:

Bing-juan Zhou,Yue-hong Li,Xiang-hong Zhang,Ling-xiao Xing,Xia Yan,Jun-ling Wang,Jing Liu,Xin Xing,

OBJECTIVE: To explore the putative effects of Vitamin C (Vit C) on inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells (HPBMCs) induced by deoxynivalenol (DON) in vitro. METHODS: The effects of Vit C on the changes of HLA-I expression of HPBMCs induced by DON in vitro were evaluated with cell culture, flow cytometry (FCM), Western blotting and immunocytochemical methods. RESULTS: FCM analysis showed that HLA-I expression of HPBMCs in DON treated cells was significantly lower than that in controls (FI 0.88 +/- 0.02 vs 1.00 +/- 0.03, P < 0.05). As compared with DON group, the HLA-I expressions of HPBMCs in the two Vit C (25 micromol/L and 100 micromol/L) pretreatment groups were all significantly increased (1.15 +/- 0.06 and 1.10 +/- 0.02 vs 0.88 +/- 0.02, P < 0.05). Exposure to different dosage of Vit C alone could dramatically increase the expression of HLA-I of HPBMCs in vitro as compared with that in the normal control (FI for 25 micromol/L and 100 micromol/L Vit C treatment group was 1.28 +/- 0.03 and 1.25 +/- 0.05 respectively, P < 0.05). Immunocytochemical results showed that the percentages of HLA-I positive expression of HPBMCs in Vit C pretreatment groups at different dosages were significantly higher than those in DON group (70.10 +/- 6.90)%, (64.50 +/- 5.50)% vs (42.20 +/- 4.30)%, P < 0.05. Western blotting confirmed the results of FCM and immunocytochemistry. CONCLUSIONS: Vitamin C pretreatment at different dosages could reverse at some extent the inhibitive effects of DON on HLA-I expression of HPBMCs.

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Publishing Authors By Initials

BJ Zhou,YH Li,XH Zhang,LX Xing,X Yan,JL Wang,J Liu,X Xing,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of

VOLUME: 40

Page Numbers: 314-8

Journal Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi

ISSN: 0253-9624

DAY: 14

MONTH: Sep

YEAR: 2006

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7904962

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]

AFFILIATION: Laboratory of Pathology, Hebei Medcial University, Shijiazhuang 050017, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Yu Fang Yi Xue Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of vitamin C on the inhibition of human leucocyte antigen class I HLA-I expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro Related Publications

• Antisense oligonucleotide of hypoxia-inducible factor-1alpha suppresses growth and tumorigenicity of lung cancer cells A549.
• Comorbidity of substance use disorders and other psychiatric disorders among adolescents: evidence from an epidemiologic survey.
• Evaluation of on-board kV cone beam CT (CBCT)-based dose calculation.
• Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer.
• QTL analysis for flag leaf characteristics and their relationships with yield and yield traits in rice.
• Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.
• [A comparison study on clinical chromatographic fingerprintings of mycolic acids analysis of 18 standard strains of Mycobacteria in China]
• [A method using long primers for cloning the upstream sequence of delta-6 fatty acid desaturases gene of Thamnidium elegans by nested inverse PCR]
• [Analysis of cellulase synthesis mechanism in Trichoderma reesei using red fluorescent protein]
• [Analysis of the incidence and survival of female breast cancer in Beijing during the last 20 years]
• [Application of contribute degree in forensic mental trauma assessments]
• [Application of the free vascularized lateral upper arm flap in intraoral reconstruction following ablative tumour surgery]
• [Compare the effect of lipo- and normal prepared Sodium Morrhuate on ECV-304 cell line]
• [Comparison of clinical outcomes of four protocols for frozen-thawed embryo transfer cycle]
• [Determination of changes in membrane phospholipids of rat lung and liver tissues from acute heat stress by high performance liquid chromatography]
• [Effects of vitamin C on apoptosis and proliferation inhibition of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]
• [Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro]
• [Expression of E-cadherin in human embryo]
• [Expression of matrix metalloproteinases in the cytotrophoblasts and decidual stromal cells in human early pregnancy]
• [Identification of Mortieralla isabellina M6-22 delta 6-fatty acid desaturase by heterologous expression in Saccharomyces cerevisiae]
• [Impact of spiral CT cholangiography on suspected obstructive jaundice]
• [Indocyanine green angiographic findings of systemic lupus erythematosus choroidopathy: a follow-up study of one patient]
• [MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease]
• [Pituitary down-regulation and ovulation stimulation with gradually increased gonadotropin in controlled ovarian hyperstimulation]
• [Preliminary study on separation of three vitamins by capillary zone electrophoresis and micellar electrokinetic chromatography with amperometric electrochemical detection]
• [Preparation and preliminary identification of the monoclonal antibody to bovine bFGF]
• [Primitive neuroectodermal tumor of bone and soft tissue]
• [Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy]
• [Study on the structure and function of a stable methane-oxidizing mixed microbial consortium]
• [Value of multislice spirral computed tomography in finding coronary artery lesion in children with Kawasaki disease]