Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase.

Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase. Research Abstract Details 

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Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase. Abstract Text:

Junya Iwai,Noriko Ogawa,Hiromasa Nagase,Tomohiro Endo,Thorsteinn Loftsson,Haruhisa Ueda,Junya Iwai,Noriko Ogawa,Hiromasa Nagase,Tomohiro Endo,Thorsteinn Loftsson,Haruhisa Ueda,

The effects of eight cyclodextrins (CDs) on the stability of freeze-dried lactate dehydrogenase (LDH) were investigated. Five low-molecular weight saccharides were used as a reference. In the samples without saccharides, LDH activity was decreased by freeze-drying. The LDH activities of the samples with 2-hydroxypropylated CDs (HP-CDs) such as 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) showed only a small decrease and were more effective protein stabilizers than low-molecular weight saccharides. HP-beta-CD more effectively stabilized LDH than trehalose, at a sugar concentration of less than 1.0 w/w% and furthermore, a close relationship existed between the highly stabilizing effect and the degree of substitution of polar substituents.

Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase. Publishing Authors By Initials

J Iwai,N Ogawa,H Nagase,T Endo,T Loftsson,H Ueda,J Iwai,N Ogawa,H Nagase,T Endo,T Loftsson,H Ueda,

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Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pharmaceutical sciences

VOLUME: 96

Page Numbers: 3140-3

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ISSN: 0022-3549

DAY: 5

MONTH: Nov

YEAR: 2007

Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of various cyclodextrins on the stability of freeze-dried lactate dehydrogenase.

AFFILIATION: Department of Physical Chemistry, Hoshi University, 4-41, Ebara 2-chome, Tokyo 142-8501, Japan.

Country: United States

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MEDLINETA: J Pharm Sci

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