Effects of thin-film structural parameters on laser desorption/ionization from porous alumina.

Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Research Abstract Details 

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Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Abstract Text:

Ranu Nayak,Daniel R Knapp,

Nanoporous aluminum oxide layers, grown by anodization of aluminum thin films on glass and then sputter-coated with gold, were used to study the effects of the thin-film structural parameters on laser desorption/ionization (LDI) mass spectrometry (MS) of peptides. Variation of MS signal intensity was examined as a function of alumina pore depth, pore width, and gold layer thickness. Peptide molecular ion intensity was optimal with porous alumina formed from aluminum films of approximately 600-nm thickness; thinner or thicker films gave significantly lower signals. Signals decreased when pore sizes were increased beyond the as-formed width of approximately 100 nm. The MS signal also varied with the thickness of the sputtered gold layer with an optimum thickness being approximately 90 nm. The results of these studies provide values for empirical optimization of LDI MS performance as well as potential clues to the LDI mechanism.

Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Publishing Authors By Initials

R Nayak,DR Knapp,

For similar natural sciences: chemistry: chemistry, physical: surface properties research abstracts see: natural sciences: chemistry: chemistry, physical: surface properties research

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MEDLINE DATE:

Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Analytical chemistry

VOLUME: 79

Page Numbers: 4950-6

Journal Abbreviation: Anal. Chem.

ISSN: 0003-2700

DAY: 5

MONTH: 06

YEAR: 2007

Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370536

Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Keywords Mesh Terms:

KEYWORDS: Surface Properties

MESH TERMS: methods

Chemical & Substance for Abstract: Effects of thin-film structural parameters on laser desorption/ionization from porous alumina. Information

Substance Name: Gold

Registry Number: 7440-57-5

Grant and Affiliation Information for Effects of thin-film structural parameters on laser desorption/ionization from porous alumina.

AFFILIATION: Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HV-28181

ACRONYM: HV

MEDLINETA: Anal Chem

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