Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Abstract Text:

Lei Chen,Wing-Ho Yung,

To elucidate the cellular action of tiagabine, an inhibitor of GAT-1 GABA transporter, in the globus pallidus, whole-cell patch-clamp recordings were made from rat globus pallidus neurons in the acutely prepared brain slice. Superfusion of tiagabine significantly prolonged the decay kinetics of both action potential-dependent and -independent (tetrodotoxin-resistant) inhibitory postsynaptic currents (IPSCs) that were mediated by GABA(A) receptors. Furthermore, it decreased the frequency of these IPSCs. The latter effect was reversed by the GABA(B) receptor antagonist CGP55845, which alone had no effect, suggesting the involvement of presynaptic GABA(B) receptors. Thus, tiagabine could inhibit or disinhibit globus pallidus neurons by increasing the activation of the GABA(A) receptors and presynaptic GABA(B) receptors, respectively. In the behaving animal, tiagabine when injected unilaterally into the globus pallidus caused consistent ipsilateral rotation of the rats indicative of increased inhibition of globus pallidus activity. This finding could be explained by the proposition that in the presence of tiagabine, prolonged action of GABA on GABA receptors would dominate over the inhibitory effect of tiagabine on GABA release. Our findings on the electrophysiological and behavioral effects of tiagabine in globus pallidus suggest that this basal ganglia nucleus is one of the sites of action of tiagabine and provides a rationale for investigating its involvement in epilepsy.

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Publishing Authors By Initials

L Chen,WH Yung,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

PUBMED ID PMID:

MEDLINE DATE:

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 152

Page Numbers: 263-9

Journal Abbreviation:

ISSN: 0014-4819

DAY: 23

MONTH: 07

YEAR: 2003

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus. Information

Substance Name: CGP 55845A

Registry Number: 148056-42-2

Grant and Affiliation Information for Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.

AFFILIATION: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus Related Publications

• 5-HT excites globus pallidus neurons by multiple receptor mechanisms.
• A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme.
• A case of cutaneous symplastic leiomyoma - a rare variant of cutaneous pilar leiomyoma.
• A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer.
• An erythematous nodule on the eyelid.
• Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.
• Avoidance of BIPP allergy hypersensitivity reactions following ear surgery.
• Can probability of genetic mutation be an indicator of clinical relevance?
• Carrying Neuro-Oncology to a World that Needs Knowledge.
• Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.
• Diffraction characteristics of photoresist surface-relief gratings.
• Early intervention in psychotic disorders: detection and treatment of the first episode and the critical early stages.
• Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha- dendritic cell function.
• Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.
• Enhanced production of human interferon-gamma by the use of a combination of inducers--phytohemagglutinin, picibanil and tumor promoting agent.
• Impact of co-occurring substance use on 6 month outcomes for young people seeking mental health treatment.
• Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
• Lane detection by orientation and length discrimination.
• Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis.
• Modulation of synaptic GABA(A) receptor function by zolpidem in substantia nigra pars reticulata.
• New drugs and new delivery techniques.
• PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
• PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.
• Potential use of cholecalciferol polyethylene glycol succinate as a novel pharmaceutical additive.
• Pseudochromhidrosis: Blue discolouration of the head and neck.
• Selectivity of folate conjugated polymer micelles against different tumor cells.
• Studying the effects of new peritoneal dialysis solutions on the peritoneum.
• Surgery for esophageal cancer: do age or incorrect data analysis have any impact on clinical outcome?
• Titanium prosthesis with malleus notch: a study of its 'user-friendliness'.
• Well-defined nanoassemblies using gold nanoparticles bearing specific number of DNA strands.