Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia.

Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Research Abstract Details 

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Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Abstract Text:

Adrian Miranda,Shachar Peles,Peter G McLean,Jyoti N Sengupta,

Conflicting results exist regarding the role of 5-HT3 receptors in somatic and visceral nociceptive processing. We aimed to investigate the effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Two injections (100 microl) of either pH 4.0 or 7.2 saline were given unilaterally in the gastrocnemius (GN) muscle. In all groups, the paw withdrawal thresholds (PWT) to von Frey filaments and the visceromotor responses (VMR) to colorectal distension (CRD) were recorded before the saline injections and 72 h, and 1 week after the second injection. Intrathecal (i.t.) (25 nmol) or intravenous (i.v.) (100 microg/kg/day) alosetron was given daily following the second injection and compared to either i.v. or i.t. saline (vehicle). There was a significant decrease in the mean PWT bilaterally in all groups following pH 4.0 injections (p<0.05). Intravenous alosetron resulted in a significant increase in the PWT bilaterally on days 2 and 3. Intrathecal alosetron resulted in significant increase in the PWT starting at day 3 and was significantly higher than baseline on days 4-7 (p<0.05). At CRD pressures 30 mmHg, the VMR of pH 4.0 injected rats was significantly increased at 72 h and 1 week (p<0.05). Both i.v. and i.t. alosetron treated rats failed to demonstrate any alteration in the VMR. Control rats (pH 7.2) failed to show any alteration in the VMR and were unaffected by alosetron. Both, systemically and centrally administered alosetron, reversed the mechanical somatic hypersensitivity and prevented the development of visceral hyperalgesia, suggesting a centrally mediated effect.

Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Publishing Authors By Initials

A Miranda,S Peles,PG McLean,JN Sengupta,

For similar body regions: viscera research abstracts see: body regions: viscera research

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Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pain

VOLUME: 126

Page Numbers: 54-63

Journal Abbreviation: Pain

ISSN: 1872-6623

DAY: 17

MONTH: 07

YEAR: 2006

Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7508686

Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Keywords Mesh Terms:

KEYWORDS: Viscera

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Information

Substance Name: alosetron

Registry Number: 122852-42-0

Grant and Affiliation Information for Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia.

AFFILIATION: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA. amiranda@mail.mcw.edu

Country: Netherlands

AGENCY: United States SAMHSA

GRANT: R01 DK062312-01AS

ACRONYM: AS

MEDLINETA: Pain

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