Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals.

Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Research Abstract Details 

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Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Abstract Text:

H Chen,A Czajka-Jakubowska,N J Spencer,J F Mansfield,C Robinson,B H Clarkson,H Chen,A Czajka-Jakubowska,N J Spencer,J F Mansfield,C Robinson,B H Clarkson,

Systemically administered fluoride at a concentration of 75 ppm increases the surface roughness of developing enamel crystals in rats, which may be significant in advancing our understanding of the biological mechanism of fluorosis. Thus, the aim of this study was to investigate whether the increased surface roughness may be a result of surface restructuring by the direct action of fluoride at the crystal surface. We examined the fluoride dose-dependent roughening of enamel crystal surfaces in vivo, in the rat, and whether this roughening could be mimicked by the in vitro treatment of rat enamel crystals with neutral pH fluoride solutions. Our results showed that enamel crystal surface roughness increased after treatment with increasing fluoride ion concentrations, whether applied in vitro or administered systemically. This suggests a mechanism, alongside others, for the increased surface roughness of crystals in fluorotic enamel.

Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Publishing Authors By Initials

H Chen,A Czajka-Jakubowska,NJ Spencer,JF Mansfield,C Robinson,BH Clarkson,H Chen,A Czajka-Jakubowska,NJ Spencer,JF Mansfield,C Robinson,BH Clarkson,

For similar natural sciences: chemistry: chemistry, physical: surface properties research abstracts see: natural sciences: chemistry: chemistry, physical: surface properties research

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MEDLINE DATE:

Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of dental research

VOLUME: 85

Page Numbers: 1042-5

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 3

MONTH: Nov

YEAR: 2006

Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 354343

Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Keywords Mesh Terms:

KEYWORDS: Surface Properties

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals. Information

Substance Name: Sodium Fluoride

Registry Number: 7681-49-4

Grant and Affiliation Information for Effects of systemic fluoride and in vitro fluoride treatment on enamel crystals.

AFFILIATION: Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N. University, Ann Arbor, MI 48109-1078, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: DE015599

ACRONYM: DE

MEDLINETA: J Dent Res

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