Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease.

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Abstract Text:

Janne Ludwig,Piet Remien,Christoph Guballa,Andreas Binder,Sabine Binder, Schattschneider,Jan Herzog,Jens Volkmann, Deuschl,Gunnar Wasner,Ralf Baron,

Dysfunctions of the autonomic nervous system (ANS) are common in Parkinson's disease (PD). Regarding motor disability, deep brain stimulation of the subthalamic nucleus (STN) is an effective treatment option in long lasting PD. The aims of this study were to examine whether STN stimulation has an influence on functions of the ANS and to compare these effects to those induced by levodopa. Blood pressure (BP) and heart rate (HR) during rest and orthostatic conditions, HR variability (HRV) and breathing-induced cutaneous sympathetic vasoconstriction (CVC) were tested in 14 PD patients treated with STN stimulation during "ON" and "OFF" condition of the stimulator. The effects of a single dose of levodopa on ANS were tested in 15 PD patients without DBS. STN stimulation had no influence on cardiovascular ANS functions, whereas CVC was significantly increased. In contrast, levodopa significantly lowered BP and HR at rest and enhanced orthostatic hypotension. Further, HRV, skin perfusion and temperature increased after administration of levodopa. Our results suggest that in contrast to levodopa, STN stimulation has only minor effects on autonomic functions. Since less pharmacotherapy is needed after STN stimulation, reduced levodopa intake results in relative improvement of autonomic function in deep brain stimulated PD patients.

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Publishing Authors By Initials

J Ludwig,P Remien,C Guballa,A Binder,S Binder,J Schattschneider,J Herzog,J Volkmann,G Deuschl,G Wasner,R Baron,

For similar vasoconstriction research abstracts see: vasoconstriction research

PUBMED ID PMID:

MEDLINE DATE:

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurology, neurosurgery, and psychiatry

VOLUME: 78

Page Numbers: 742-5

Journal Abbreviation: J. Neurol. Neurosurg. Psychiat

ISSN: 1468-330X

DAY: 19

MONTH: 03

YEAR: 2007

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985191

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Vasoconstriction

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease. Information

Substance Name: Levodopa

Registry Number: 0

Grant and Affiliation Information for Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease.

AFFILIATION: Division of Neurological Pain Research and Therapy, University of Kiel, Kiel, Germany. j.ludwig@neurologie.uni-kiel.de

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurol Neurosurg Psychiatry

REFSOURCE: J Neurol Neurosurg Psychiatry. 2007 Dec;

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease Related Publications

• A comparison of computerized dynamic posturography therapy to standard balance physical therapy in individuals with Parkinson's disease: A pilot study.
• A glance into the Book of Abstracts - Second International Congress on Neuropathic Pain.
• Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry.
• Are the Short Form 36 physical and mental component summary scores useful measures in patients with systemic sclerosis? Comment on the article by Rannou et al.
• Behavioural Assessment of the Dysexecutive Syndrome for Children (BADS-C) by Emslie, H., Wilson, F. C., Burden, V., Nimmo-Smith, I., & Wilson, B. A. (2003).
• Biochemical identification of bovine spongiform encephalopathies in cattle.
• Characterization of oxidative changes in salted herring (Clupea harengus) during ripening.
• Clinically significant delayed postsphincterotomy bleeding: a twelve year single center experience.
• Closure of a duodenal stent-induced perforation by endoscopic stent removal and covered self-expandable metal stent placement (with video).
• Combined use of surgery and radiation in the treatment of an intradural myxoid liposarcoma in a dog.
• Effect of topical vitamin D analogue on in vivo contact sensitization.
• Effects of subthalamic nucleus stimulation and levodopa on the autonomic nervous system in Parkinson's disease.
• Endoscopic retrograde cholangiopancreatography tissue sampling: when and how?
• Expandable gastrointestinal stents.
• Functional imaging of working memory in Parkinson's disease: compensations and deficits.
• Gradients in bone morphogenetic protein-related gene expression across the growth plate.
• Hypocomplementemia in systemic sclerosis--clinical and serological correlations.
• Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.
• Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
• Molecular regulation of osteoclast activity.
• Palliative use of percutaneous endoscopic gastrostomy and percutaneous endoscopic cecostomy tubes.
• Postherpetic neuralgia: epidemiology, pathophysiology and management.
• Regulation of growth plate chondrogenesis by bone morphogenetic protein-2.
• Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
• Stenting of the proximal colon in patients with malignant large bowel obstruction: techniques and outcomes.
• The VirB5 protein localizes to the T-pilus tips in Agrobacterium tumefaciens.
• The management of postacne scarring.
• The skin, carotid and intervertebral disc: making the connection!
• Update on indices of disease activity in systemic sclerosis.
• Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation.