Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults.

Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Research Abstract Details 

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Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Abstract Text:

Joseph V Agostini,Mary E Tinetti,Ling Han,Gail McAvay,Joanne M Foody,John Concato,

OBJECTIVES: To determine the relationship between hydroxymethyl glutaryl coenzyme A reductase inhibitor (statin) use and proximal muscle strength, cognition, and depression in older adults. DESIGN: Observational cohort study. SETTING: Outpatient primary care clinics. PARTICIPANTS: Seven hundred fifty-six community-dwelling veterans aged 65 and older. MEASUREMENTS: Timed chair stands (a measure of proximal muscle strength), Trail Making Test Part B (a measure of cognition), and the Center for Epidemiologic Studies Depression Scale score were measured at baseline and 1-year follow-up. Participants were assessed for statin prescriptions (and indications for or contraindications to their use), concomitant medication use, comorbidities, and other potential confounders. RESULTS: Statin users (n=315) took a mean 6.6 medications, versus 4.6 for nonusers (n=441), and had a median duration of statin use of 727 days. Statin users were more likely to be white and had (as expected) more cardiac, cerebrovascular, and peripheral vascular disease. Based on multivariable models adjusting for pertinent covariates, statin users performed modestly better than nonusers for timed chair stands (-0.5 seconds; P=.04), Trail Making Test Part B (-7.7 seconds; P=.08), and depression scores (-0.2 points; P=.49) at follow-up. Of potentially high-risk participants (based on age, comorbidity, and number of medications), statin users also showed similar 1-year changes as nonusers, although worsened depression scores were found in those with greater comorbidity (+0.88 points; P=.10). CONCLUSION: Older, community-dwelling male participants taking maintenance statin therapy had similar outcomes to those of nonusers in tests of muscle strength, cognition, and depression, but further examination of benefits and harms in different subgroups is warranted.

Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Publishing Authors By Initials

JV Agostini,ME Tinetti,L Han,G McAvay,JM Foody,J Concato,

For similar persons: veterans research abstracts see: persons: veterans research

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Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Geriatrics Society

VOLUME: 55

Page Numbers: 420-5

Journal Abbreviation:

ISSN: 0002-8614

DAY: 3

MONTH: Mar

YEAR: 2007

Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Keywords Mesh Terms:

KEYWORDS: Veterans

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. Information

Substance Name: Hydroxymethylglutaryl-CoA Reductase Inhi

Registry Number: 0

Grant and Affiliation Information for Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults.

AFFILIATION: Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA. joseph.agostini@yale.edu

Country: United States

AGENCY: United States NIA

GRANT: P30-AG21342

ACRONYM: AG

MEDLINETA: J Am Geriatr Soc

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