Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.

Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Research Abstract Details 

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Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Abstract Text:

Charles E Wood,Thomas B Clarkson,Susan E Appt,Adrian A Franke,Stephen M Boue,Matthew E Burow,Thomas McCoy,J Mark Cline,

Glyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.

Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Publishing Authors By Initials

CE Wood,TB Clarkson,SE Appt,AA Franke,SM Boue,ME Burow,T McCoy,JM Cline,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nutrition and cancer

VOLUME: 56

Page Numbers: 74-81

Journal Abbreviation:

ISSN: 0163-5581

DAY: 3

MONTH: 12

YEAR: 2006

Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905040

Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: chemistry

Chemical & Substance for Abstract: Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Information

Substance Name: glyceollin

Registry Number: 57103-57-8

Grant and Affiliation Information for Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.

AFFILIATION: Department of Pathology/Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. chwood@wfubmc.edu

Country: United States

AGENCY: United States NCRR

GRANT: T32 RR 07009

ACRONYM: RR

MEDLINETA: Nutr Cancer

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