Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat.

Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Research Abstract Details 

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Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Abstract Text:

G Flemström,G Jedstedt,O Nylander,

Bicarbonate secretion by 12 mm segments of duodenum just distal to the Brunner's glands area and devoid of pancreatic bicarbonate was titrated in situ in anaesthetised rats. The secretion increased significantly after intravenous injection of small amounts (20 ng/kg) of the endogenous opioid peptides beta-endorphin and methionine enkephalin and maximal (approximately twofold) stimulation occurred after 200-500 ng/kg. Morphine (50 micrograms/kg) caused a similar stimulation and the mu-opiate antagonist naloxone prevented stimulation by morphine. The synthetic analogue [D-Ala2, D-Leu5]-enkephalin (500 ng/kg) which is an agonist at delta-opiate receptors, did not affect the secretion, further suggesting that stimulation is mediated by mu-receptors. VIP (5-100 micrograms/kg) increased the secretion dose-dependently to levels considerably higher than those observed with opiates, and pretreatment with atropine or indomethacin did not affect the response to VIP. The results suggest a role of endogenous opioid peptides and VIP in the humoral and/or nervous control of duodenal surface epithelial bicarbonate secretion and mucosal protection.

Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Publishing Authors By Initials

G Flemström,G Jedstedt,O Nylander,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: gastrointestinal hormones: vasoactive intestinal peptide research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: gastrointestinal hormones: vasoactive intestinal peptide research

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Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 110

Page Numbers: 49-53

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1985

Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 437034

Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Keywords Mesh Terms:

KEYWORDS: Vasoactive Intestinal Peptide

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Effects of some opiates and vasoactive intestinal peptide (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Information

Substance Name: Enkephalin, Methionine

Registry Number: 58569-55-4

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Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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