Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat.

Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Research Abstract Details 

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Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Abstract Text:

Sunil Kumar,Ronald Szymusiak,Tariq Bashir,Seema Rai,Dennis McGinty,Md Noor Alam,

The hypocretin (HCRT) system of the perifornical-lateral hypothalamic area (PF-LHA) has been implicated in the facilitation of behavioral arousal. HCRT neurons receive serotonergic afferents from the dorsal raphe nucleus. Although in-vitro pharmacological studies suggest that serotonin (5-HT) inhibits HCRT neurons, the in-vivo effects of 5-HT on HCRT neurons in the PF-LHA and associated behavioral changes have not been described. We examined the effects of 5-HT delivered locally into the PF-LHA using reverse microdialysis on its neuronal activity and the consequent sleep-wake changes in rats. First, we quantified Fos expression (Fos-IR) in HCRT and other PF-LHA neurons following unilateral 5-HT perfusion in awake rats. Second, we determined the transient effects of 5-HT perfusion on the extracellular activity of the PF-LHA neurons recorded via microwires placed adjacent to the microdialysis probe. Third, we examined the effects of 5-HT perfusion into the PF-LHA on the sleep-wake profiles of the rats during the lights-off period. Unilateral perfusion of 5-HT into the PF-LHA in awake rats dose-dependently decreased the number of HCRT neurons exhibiting Fos-IR. 5-HT also inhibited the discharge activity of four of five responsive wake-related, putative HCRT neurons. However, unilateral perfusion of 5-HT into the PF-LHA did not produce significant behavioral changes during the 2-h recording period. These results confirm the in-vitro findings that 5-HT exerts inhibitory influences on HCRT neurons but further suggest that the inactivation of a limited number of HCRT neurons by unilateral 5-HT microdialysis may not be sufficient to induce behavioral changes.

Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Publishing Authors By Initials

S Kumar,R Szymusiak,T Bashir,S Rai,D McGinty,MN Alam,

For similar arousal: wakefulness research abstracts see: arousal: wakefulness research

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MEDLINE DATE:

Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 201-12

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 3

MONTH: Jan

YEAR: 2007

Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Keywords Mesh Terms:

KEYWORDS: Wakefulness

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for Effects of serotonin on perifornical-lateral hypothalamic area neurons in rat.

AFFILIATION: Research Service (151A3), Veteran Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA.

Country: France

AGENCY: United States NINDS

GRANT: NS-050939

ACRONYM: NS

MEDLINETA: Eur J Neurosci

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