Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.

Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons. Research Abstract Details 

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Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons. Abstract Text:

Dongping Tian,Min Su,Xianying Wu,Qiaoshan Li,Ruiming Zheng,Guangyuan Li,Tianbao Song,Xiaohu Xu,

OBJECTIVE: To study the effect of selenium (Se) and iodine (I) and the compound of both on the proto-oncogenes c-fos and c-jun mRNA and their protein expression in the cultured rat hippocampus neurons. METHODS: Using the technique of serum free hippocampus neuron culture, different doses of Se and I and Se + I compound were added into the medium. The expression of the mRNA of c-fos, c-jun in hippocampus neurons cultured for 1, 3, 5, 7 and 10 d were studied using both in situ hybridization and SABC immunohistochemical technique. RESULTS: Both Se and I could enhance the expression of c-fos, c-jun mRNA and their proteins, especially the combination of I and Se able to give a remarkable effect on c-jun mRNA expression. CONCLUSIONS: Se and I may effect the expression of both c-fos and c-jun mRNA, especially the c-jun mRNA and its protein of hippocampus neurons, and thus may effect the differentiation and development of neurons.

Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons. Publishing Authors By Initials

D Tian,M Su,X Wu,Q Li,R Zheng,G Li,T Song,X Xu,

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Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua bing li xue za zhi Chinese journal of pat

VOLUME: 31

Page Numbers: 245-9

Journal Abbreviation: Zhonghua Bing Li Xue Za Zhi

ISSN: 0529-5807

DAY: 11

MONTH: Jun

YEAR: 2002

Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.

AFFILIATION: Department of Pathology, Shantou University Medical College, Shantou 515031, China (Email: minsu@ncrc.stu.edu.cn)

Country: China

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MEDLINETA: Zhonghua Bing Li Xue Za Zhi

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