Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency.

Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Research Abstract Details 

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Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Abstract Text:

Recombinant human insulin-like growth factor I (IGF-I), 40 micrograms/kg/body weight, was administered subcutaneously at 08.00 hours to six adult patients with growth hormone deficiency (GHD). The mean maximal IGF-I concentrations were found 2-6 hours after injection. Concentrations then gradually declined, though mean values were still above basal 24 hours after the injection. Only one patient maintained IGF-I levels above the lower normal range throughout 24 hours. There was a significant decrease in mean IGF-II concentrations when measured 4 and 24 hours after injection of IGF-I. The diurnal variations of insulin and IGF binding protein-1 were preserved. There were no side-effects, and blood glucose remained normal. These results show that in patients with low IGF-I levels resulting from GHD, it is necessary to administer IGF-I at intervals of less than 24 hours to obtain IGF-I levels that are within the normal range.

Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Publishing Authors By Initials

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta paediatrica (Oslo, Norway : 1992). Supplement

VOLUME: 388

Page Numbers: 45-8

Journal Abbreviation: Acta Paediatr Suppl

ISSN: 0803-5326

DAY: 12

MONTH: Mar

YEAR: 1993

Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Information

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LANGUAGE: eng

NlmUniqueID: 9315043

Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Effects of recombinant human insulin-like growth factor I administration in adults with growth hormone deficiency.

AFFILIATION: Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.

Country: SWEDEN

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MEDLINETA: Acta Paediatr Suppl

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