Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy.

Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Research Abstract Details 

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Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Abstract Text:

Mark E Williams,W Kline Bolton,Raja G Khalifah,Thorsten P Degenhardt,Robert J Schotzinger,Janet B McGill,Mark E Williams,W Kline Bolton,Raja G Khalifah,Thorsten P Degenhardt,Robert J Schotzinger,Janet B McGill,

BACKGROUND/AIMS: Treatments of diabetic nephropathy (DN) delay the onset of end-stage renal disease. We report the results of safety/tolerability studies in patients with overt nephropathy and type 1/type 2 diabetes treated with pyridoxamine, a broad inhibitor of advanced glycation. METHODS: The two 24-week studies were multicenter Phase 2 trials in patients under standard-of-care. In PYR-206, patients were randomized 1:1 and had baseline serum creatinine (bSCr) or=2.0 but or=1.3 mg/dl, type 2 diabetes), a treatment effect was observed on the rise in serum creatinine (p = 0.007). No differences in urinary albumin excretion were seen. Urinary TGF-beta1 also tended to decrease with pyridoxamine (p = 0.049) as did the CML and CEL AGEs. CONCLUSION: These data provide a foundation for further evaluation of this AGE inhibitor in DN.

Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Publishing Authors By Initials

ME Williams,WK Bolton,RG Khalifah,TP Degenhardt,RJ Schotzinger,JB McGill,ME Williams,WK Bolton,RG Khalifah,TP Degenhardt,RJ Schotzinger,JB McGill,

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Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of nephrology

VOLUME: 27

Page Numbers: 605-14

Journal Abbreviation: Am. J. Nephrol.

ISSN: 1421-9670

DAY: 6

MONTH: 09

YEAR: 2007

Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy. Information

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LANGUAGE: eng

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AFFILIATION: Harvard Medical School, Joslin Diabetes Center, Boston, MA 02215, USA. mark.williams@joslin.harvard.edu

Country: Switzerland

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MEDLINETA: Am J Nephrol

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