Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland.

Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Research Abstract Details 

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Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Abstract Text:

Wieslaw Jedrychowski,Jeffery Jankowski,Elzbieta Flak,Anita Skarupa,Elzbieta Mroz,Elzbieta Sochacka-Tatara,Iwona Lisowska-Miszczyk,Agnieszka Szpanowska-Wohn,Virginia Rauh,Zbigniew Skolicki,Irena Kaim,Frederica Perera,

PURPOSE: The aim of the study is to assess the cognitive and psychomotor status of 1-year-old infants whose mothers were exposed to low, but varying, amounts of mercury during pregnancy. METHODS: Mercury levels in cord and maternal blood at delivery were used to assess prenatal environmental exposure to mercury. Bayley Scales of Infant Development were used to assess neurobehavioral health outcomes. The cohort consisted of 233 infants who were born at 33 to 42 weeks of gestation between January 2001 and March 2003 to mothers attending ambulatory prenatal clinics in the first and second trimesters of pregnancy. Enrollment included only nonsmoking women with singleton pregnancies between the ages of 18 and 35 years who were free from chronic diseases. RESULTS: The geometric mean (GM) for maternal blood mercury level for the group of infants with normal neurocognitive performance was lower (GM = 0.52 mug/L; 95% confidence interval [CI], 0.46-0.58) than that observed in the group with delayed performance (GM = 0.75 mug/L; 95% CI, 0.59-0.94), and this difference was significant (p = 0.010). The GM of cord blood mercury level in the normal group also was lower (GM = 0.85 mug/L; 95% CI, 0.78-0.93) than that observed in the group with delayed performance (GM = 1.05 mug/L; 95% CI, 0.87-1.27), and this difference was of borderline significance (p = 0.070). The relative risk (RR) for delayed performance increased more than threefold (RR = 3.58; 95% CI, 1.40-9.14) if cord blood mercury level was greater than 0.80 mug/L. Risk for delayed performance in the group of infants with greater maternal mercury levels (>0.50 mug/L) also was significantly greater (RR = 2.82; 95% CI, 1.17-6.79) compared with children whose mothers had mercury levels less than 0.50 mug/L. CONCLUSIONS: The results may be of public health importance because delayed psychomotor or mental performance in infants is assumed to be an indicator of later neurocognitive development in children, which may persist into adult life.

Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Publishing Authors By Initials

W Jedrychowski,J Jankowski,E Flak,A Skarupa,E Mroz,E Sochacka-Tatara,I Lisowska-Miszczyk,A Szpanowska-Wohn,V Rauh,Z Skolicki,I Kaim,F Perera,

For similar psychological phenomena and processes: psychomotor performance research abstracts see: psychological phenomena and processes: psychomotor performance research

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Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of epidemiology

VOLUME: 16

Page Numbers: 439-47

Journal Abbreviation:

ISSN: 1047-2797

DAY: 7

MONTH: 11

YEAR: 2005

Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100013

Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Keywords Mesh Terms:

KEYWORDS: Psychomotor Performance

MESH TERMS: drug effects

Chemical & Substance for Abstract: Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Information

Substance Name: Mercury

Registry Number: 7439-97-6

Grant and Affiliation Information for Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland.

AFFILIATION: Chair of Epidemiology and Preventive Medicine, College of Medicine, Jagiellonian University, Krakow, Poland. myjedryc@cyf-kr-edu.pl

Country: United States

AGENCY: United States NIEHS

GRANT: 5 R01 ES10165

ACRONYM: ES

MEDLINETA: Ann Epidemiol

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