Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Abstract Text:

Takahiro Ohnishi,Tomohisa Yoshida,Arisa Igarashi,Masashi Muroi,Ken-Ichi Tanamoto,

Endocrine disrupting chemicals (EDCs) may potentially worsen infectious diseases because EDCs disturb human immune function by interfering with endocrine balance. To evaluate the influence of EDCs on the innate immune function of macrophages, we investigated the effects of 37 possible EDCs on lipopolysaccharide-induced activation of the IFN-beta promoter. Alachlor, atrazine, benomyl, bisphenol A, carbaryl, diethyl phthalate, dipropyl phthalate, kelthane, kepone, malathion, methoxychlor, octachlorostyrene, pentachlorophenol, nonyl phenol, p-octylphenol, simazine and ziram all inhibited the activation. Kepone and ziram showed strong inhibitory effects. Aldicarb, amitrole, benzophenone, butyl benzyl phthalate, 2,4-dichlorophenoxy acetic acid, dibutyl phthalate, 2,4-dichlorophenol, dicyclohexyl phthalate, diethylhexyl adipate, diethylhexyl phthalate, dihexyl phthalate, di-n-pentyl phthalate, methomyl, metribuzin, nitrofen, 4-nitrotoluene, permethrin, trifluralin, 2,4,5-trichlorophenoxyacetic acid and vinclozolin had no significant effects at 100 muM. These results indicate that some agrochemicals and resin-related chemicals may potentially inhibit macrophage function, which suggests that endocrine disruptors may influence the development of infectious diseases.

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Publishing Authors By Initials

T Ohnishi,T Yoshida,A Igarashi,M Muroi,K Tanamoto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEMS immunology and medical microbiology

VOLUME: 52

Page Numbers: 293-5

Journal Abbreviation: FEMS Immunol. Med. Microbiol.

ISSN: 0928-8244

DAY: 20

MONTH: 12

YEAR: 2007

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9315554

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.

AFFILIATION: Division of Microbiology, National Institute of Health Sciences, Setagaya, Tokyo, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: FEMS Immunol Med Microbiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling Related Publications

• A novel TLR4-binding peptide that inhibits LPS-induced activation of NF-kappaB and in vivo toxicity.
• Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling.
• Migration of lactic acid, lactide and oligomers from polylactide food-contact materials.
• MyD88-induced downregulation of IRAK-4 and its structural requirements.
• Neocrocin A: a novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow.
• Quantitative nuclear magnetic resonance spectroscopic determination of the oxyethylene group content of polysorbates.
• TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-{kappa}B.
• [Analysis of constituents of ester-type gum bases used as natural food additives]
• [Survey of synthetic disinfectants in grapefruit seed extract and its compounded products]