Effects of polymicrobial communities on host immunity and response.

Effects of polymicrobial communities on host immunity and response. Research Abstract Details 

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Effects of polymicrobial communities on host immunity and response. Abstract Text:

Xiaoying Lu,Zoya Kurago,Kim A Brogden,

Microorganisms grow as members of microbial communities in unique niches, such as the mucosal surfaces of the human body. These microbial communities, containing both commensals and opportunistic pathogens, serve to keep individual pathogens 'in check' through a variety of mechanisms and complex interactions, both between the microorganisms themselves and the microorganisms and the host. Recent studies shed new light on the diversity of microorganisms that form the human microbial communities and the interactions these microbial communities have with the host to stimulate immune responses. This occurs through their recognition by dendritic cells or their ability to induce differential cytokine and defensin profiles. The differential induction of defensins by commensals and pathogens and the ability of the induced defensins to interact with the antigens from these microorganisms may attenuate proinflammatory signaling and trigger adaptive immune responses to microbial antigens in a multistep process. Such an activity may be a mechanism that the host uses to sense what is on its mucosal surfaces, as well as to differentiate among commensals and pathogens.

Effects of polymicrobial communities on host immunity and response. Publishing Authors By Initials

X Lu,Z Kurago,KA Brogden,

For similar biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immunity, natural research

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Effects of polymicrobial communities on host immunity and response. Journal Published:

PUBLICATION TYPE: Review

Journal: FEMS microbiology letters

VOLUME: 265

Page Numbers: 141-50

Journal Abbreviation: FEMS Microbiol. Lett.

ISSN: 0378-1097

DAY: 3

MONTH: Dec

YEAR: 2006

Effects of polymicrobial communities on host immunity and response. Information

Number of References: 103

LANGUAGE: eng

NlmUniqueID: 7705721

Effects of polymicrobial communities on host immunity and response. Keywords Mesh Terms:

KEYWORDS: Immunity, Natural

MESH TERMS: physiology

Chemical & Substance for Abstract: Effects of polymicrobial communities on host immunity and response. Information

Substance Name: Defensins

Registry Number: 0

Grant and Affiliation Information for Effects of polymicrobial communities on host immunity and response.

AFFILIATION: Department of Periodontics and Dows Institute for Dental Research, N401, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA.

Country: England

AGENCY: United States NIDCR

GRANT: R01 DE014390

ACRONYM: DE

MEDLINETA: FEMS Microbiol Lett

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