Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution.

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Abstract Text:

Ryo Saiki,Masako Okazaki,Shinichi Iwai,Toshio Kumai,Shinichi Kobayashi,Katsuji Oguchi,Ryo Saiki,Masako Okazaki,Shinichi Iwai,Toshio Kumai,Shinichi Kobayashi,Katsuji Oguchi,

We examined oxidative stress and metabolic characteristics of the spontaneously hypertensive hyperlipidemic rat (SHHR) when it was fed a high-fat diet and sucrose solution (HFDS) after N(G)-nitro-L-arginine methyl ester ingestion to develop a rat model of metabolic syndrome. This study was carried out to assess the effects of pioglitazone on levels of lipid peroxide (LPO), Cu,Zn superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), and non-esterified fatty acids (NEFA) in the plasma and liver tissue in HFDS-SHHR compared with Sprague-Dawley rats (SD). In the HFDS-treated groups, levels of LPO, CAT, GPx, and NEFA were elevated and levels of Cu,Zn-SOD were reduced in the plasma and liver tissue, with a marked accumulation of visceral fat. The changes induced by HFDS feeding were severe in the SHHR model that had essential hypertension and hyperlipidemia, when compared with SD that did not have these essential risk factors. Subcutaneous injection of 10 mg/kg per day of pioglitazone for 2 months significantly restored levels of LPO, CAT, GPx, Cu,Zn-SOD, and NEFA in the HFDS-SHHR group, and visceral fat accumulation was reduced. These results suggest that HFDS-SHHR is a suitable model of metabolic syndrome and that pioglitazone treatment can improve oxidative dysregulation in this rat model.

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Publishing Authors By Initials

R Saiki,M Okazaki,S Iwai,T Kumai,S Kobayashi,K Oguchi,R Saiki,M Okazaki,S Iwai,T Kumai,S Kobayashi,K Oguchi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmacological sciences

VOLUME: 105

Page Numbers: 157-67

Journal Abbreviation: J. Pharmacol. Sci.

ISSN: 1347-8613

DAY: 29

MONTH: 09

YEAR: 2007

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101167001

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution.

AFFILIATION: Department of Pharmacology, Showa University School of Medicine, Tokyo, Japan. ryou-777@zj8.so-net.ne.jp

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharmacol Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution Related Publications

• A multicenter phase II study of local radiation therapy for stage IEA mucosa-associated lymphoid tissue lymphomas: a preliminary report from the Japan Radiation Oncology Group (JAROG).
• Detection of human papillomavirus infection in squamous tumours of the conjunctiva and lacrimal sac by immunohistochemistry, in situ hybridisation, and polymerase chain reaction.
• Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution.
• Evidence based quality management of the clinical formulations: determination of the expiration date of the powdered medicine prepared by grinding tablets.
• Formulation study of intravesical oxybutynin instillation solution with enhanced retention in bladder.
• Glyceraldehyde-3-phosphate dehydrogenases from human erythrocytes.
• Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells.
• Internal iliac artery aneurysm rupture with aorto-enteric fistula after reconstruction of abdominal aortic aneurysm: report of a case.
• Matrix metalloproteinase-9 in spontaneously hypertensive hyperlipidemic rats.
• ON-pathway disturbance in two siblings.
• Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker.
• Scanning laser Doppler flowmeter study of retinal blood flow in macular area of healthy volunteers.